allosteric


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Related to allosteric: allosteric site

al·lo·ster·ic

 (ăl′ə-stĕr′ĭk)
adj.
Of or relating to the binding of a molecule to an enzyme at a site other than the active site, resulting in modulation of the enzyme's activity as a result of a change in its shape.

al′lo·ster′i·cal·ly adv.
al·los′ter·y (ə-lŏs′tə-rē) n.

allosteric

(ˌæləʊˈstɪərɪk)
adj
(Biochemistry) biochem of, relating to, or designating a function of an enzyme in which the structure and activity of the enzyme are modified by the binding of a metabolic molecule

al•lo•ster•ic

(ˌæl əˈstɛr ɪk, -ˈstɪər-)

adj.
of or pertaining to a change in the activity of an enzyme at a site other than the binding site of the substrate.
[1960–65]
al`lo•ster′i•cal•ly, adv.
al`lo•ster′ism
References in periodicals archive ?
A loss of allosteric regulation on the CBS enzyme activity by AdoMet was found to increase the homocysteine level [12].
He adds that the technique could be applied not only to protein folding intermediates, but any conformational change in proteins including allosteric transitions and macromolecular assembly.
Thus it provides a simple and convenient method to describe both negative and positive allosteric moderation of (biological) reaction networks.
Cambridge, Mass.-based Anchor Therapeutics announced the publication of new research that describes the identification and characterization of a pepducin-based allosteric agonist that targets CXCR4, a chemokinc G protein-coupled receptor (GPCR) found on hematopoietic stem cells and other bone marrow-derived cells.
Chapters deal with pharmacological subjects such as allosteric modulators, receptor dimerization, GPCR deorphanization, G protein activation, and the Frizzled family; methods to screen GPCR using biochemical techniques, cell phenotype, resonance energy transfer, label-free detection, and ultra-high-throughput screening; new ways to express and crystallize the receptors; computational studies such as modeling and rational drug design; and the use of pharmacological chaperones for diseases caused by GPCR mutations.
Eszopiclone is a non-benzodiazepine type allosteric GABA agonist discovered by Sepracor.
The Ii-Key motif from the Ii protein acts at an allosteric site adjacent to the MHC class II antigenic peptide-binding trough to enhance presentation of covalently linked epitopes 200-500 times in vitro.
The topics covered in the subsequent chapters include characterization of enzyme activity by the equilibrium and steady-state models; reversible, irreversible, and mechanism-based (alternate and suicide inhibition) enzyme inhibition; effects of pH on enzyme reactions; mechanisms of enzyme reactions; two- and multisubstrate reactions; immobilized, interfacial, and allosteric enzymes; transient phases of enzyme reactions; and enzyme stability.
This platform allows us to identify novel pharmacologically active compounds, such as inverse agonists and allosteric modulators, that regulate GPCR function," stated Dominic Behan, one of Arena's founders and Vice President, Research.
The oxygen binding affinity of natural human hemoglobin is too high when it is free in the blood stream (not contained within erythrocytes) because of a lack of allosteric control.
This property is allostery, and a protein is allosteric if it can increase or decrease its ability to participate in a reaction.