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Of or relating to the binding of a molecule to an enzyme at a site other than the active site, resulting in modulation of the enzyme's activity as a result of a change in its shape.

al′lo·ster′i·cal·ly adv.
al·los′ter·y (ə-lŏs′tə-rē) n.


the condition of a protein (such as an enzyme) in which the structure and activity of the enzyme are modified by the binding of a metabolic molecule at a site other than the chemically active one
References in periodicals archive ?
2005) Allosterism at muscarinic receptors: ligands and mechanisms.
Conventional peptide therapeutics used previously known to acts as ligands to manipulate function of target protein by its specific extracellular binding, and now they also acts as inhibitory properties for intracellular protein-protein interaction through allosterism [26].