According to the company, the proceeds will be used to accelerate the development of its pipeline, to expand its mutation, allostery
and pharmacology computational and discovery platform for identifying and targeting allosteric oncogenic mutations, to establish its new corporate headquarters in Cambridge, MA, advance two-to-three existing development candidates into the clinic as well as to bolster its platform's ability to identify precision medicines for mutant cancers intractable to standard care.
During its stealth stage, Black Diamond built and established proof of concept for its MAP (mutation, allostery
and pharmacology) platform to uncover, discover and target allosteric mutant oncogenes.
The structure of bovine glutamate dehydrogenase provides insights into the mechanism of allostery
. Structure 1999;7:769-82.
The differential pleiotrophy of mutations in TF loci has been attributed to an ensemble nature to allostery
of intrinsically disordered proteins , but alternatively differential pleiotrophy may also be an expected outcome in the model of limited specificity.
 applied molecular dynamics simulations and structural analyses to elucidate mechanisms of mutation-induced allostery
Machado et al., "Conformational rigidity and protein dynamics at distinct timescales regulate PTP1B activity and allostery
," Molecular Cell, vol.
has remained as a key theory in biology and biochemistry since the quantitative explanation this theory allows regarding the biological activity of oligomeric proteins is fundamental for understanding a variety of cellular processes such as hormone action, gene repression and enzyme kinetics, among others.
(2013) Modulation of allostery
by protein intrinsic disorder.
As shown in Figure 4(b), the minima of the average commute time (C(i)) indicate the key residues for T-Hb allostery
. The profiles of average commute times for [[alpha].sub.1] chain and [[beta].sub.1] chain indicate that Val10 , Leu29 , Arg31 , Thr39 , Cys104 , Val107, His122, and Leu125 in [[alpha].sub.1] chain and Ala27, Val109, Cys112, and Gln127 in [[beta].sub.1] chain are residues with highest communication abilities.
Monrovia, CA, August 27, 2016 --(PR.com)-- Terry Hebert, Professor of Pharmacology and Therapeuticsat at McGill University, will give a presentation on, "Assessing Bias and Allostery
in GPCRs using Conformational Biosensors" at GTCbio's 4th GPCR in Drug Discovery Conference to be held on September 14-15, 2016 in Boston, MA.
Specific topics include from classical thermo-chemistry to monitoring living organisms, thermotropic properties of ceramides in aqueous or lipidic environments, allostery
and cooperative interactions in proteins assessed by isothermal titration calorimetry, protein stability in crowded environments, and calorimetry to monitoring mixed bacterial populations and biofilms.