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Related to allostery: angiostenosis, analgia, arthrosteitis


Of or relating to the binding of a molecule to an enzyme at a site other than the active site, resulting in modulation of the enzyme's activity as a result of a change in its shape.

al′lo·ster′i·cal·ly adv.
al·los′ter·y (ə-lŏs′tə-rē) n.


the condition of a protein (such as an enzyme) in which the structure and activity of the enzyme are modified by the binding of a metabolic molecule at a site other than the chemically active one
References in periodicals archive ?
2013) Modulation of allostery by protein intrinsic disorder.
com)-- Terry Hebert, Professor of Pharmacology and Therapeuticsat at McGill University, will give a presentation on, "Assessing Bias and Allostery in GPCRs using Conformational Biosensors" at GTCbio's 4th GPCR in Drug Discovery Conference to be held on September 14-15, 2016 in Boston, MA.
Specific topics include from classical thermo-chemistry to monitoring living organisms, thermotropic properties of ceramides in aqueous or lipidic environments, allostery and cooperative interactions in proteins assessed by isothermal titration calorimetry, protein stability in crowded environments, and calorimetry to monitoring mixed bacterial populations and biofilms.
In summary we will develop a method that will make it possible to describe some of the most fascinating biological phenomena, such as allostery and signal transduction, and will, in the long term, be an instrument for the discovery of drugs to treat castration resistant prostate cancer, a late stage of prostate cancer that is incurable and kills ca.
The greatest potential for impact is in drug discovery and understanding biophysical processes--fundamental questions like allostery," he says, referring to the subtle process by which biological molecules go about binding to one another.