The study published in the journal 'Scientific Reports,' demonstrates the role of protein- alpha-synuclein
in preventing the death of neurons in brain diseases such as Parkinson's.
When aggregated in the brain, alpha-synuclein
is a pathological hallmark of Parkinsonian conditions and it is considered an important biologic target for treating these neurodegenerative diseases, the company said.
is a normal protein that all of us have," said Mehra.
Trojanowski's research focuses on neurodegeneration and has led to the novel view that major disease-related proteins including Tau, alpha-synuclein
and TDP-43, are co-deposited in most neurodegenerative diseases and how these copathologies impact the clinical representation of these diseases.
Estrogen also led to lower levels of alpha-synuclein
in the animals' brains.A
Masliah, "Beta-Synuclein inhibits alpha-synuclein
aggregation: a possible role as an anti-parkinsonian factor," Neuron, vol.
oligomers--neurotoxic molecules in Parkinson's disease and other Lewy body disorders," Frontiers in Neuroscience, vol.
(a) Regions of interest, with ([MSA.sup.+], in red) and without ([MSA.sup.-], in white) aggregated alpha-synuclein
staining were defined according to immunofluorescence ((A) MSA patient and (D) CTL subject).
Perhaps Corynebacterium in the GI tract induces expression of alpha-synuclein
protein, a major component of PD Lewy bodies that's known to travel from the gut to the brain.
The researchers found that cardiolipin -- a molecule inside nerve cells -- helps ensure that a protein called alpha-synuclein
One of the hallmarks of Parkinson's disease is an amyloid formation of a particular human protein, called alpha-synuclein
is even sometimes referred to as the 'Parkinson's protein'.
is a protein that is mis-folded and aggregates in PD, potentially driving disease progression.