alpha-synuclein


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al·pha-sy·nu·cle·in

 (ăl′fə-sĭ-no͞o′klē-ĭn, -nyo͞o′-)
n.
A polypeptide protein found primarily in brain neurons but seen also in the fibrils in Parkinson's disease, in the amyloid plaques of Alzheimer's disease, and in brain tissue affected by other neurodegenerative diseases.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
The study published in the journal 'Scientific Reports,' demonstrates the role of protein- alpha-synuclein in preventing the death of neurons in brain diseases such as Parkinson's.
When aggregated in the brain, alpha-synuclein is a pathological hallmark of Parkinsonian conditions and it is considered an important biologic target for treating these neurodegenerative diseases, the company said.
"Alpha-synuclein is a normal protein that all of us have," said Mehra.
Trojanowski's research focuses on neurodegeneration and has led to the novel view that major disease-related proteins including Tau, alpha-synuclein and TDP-43, are co-deposited in most neurodegenerative diseases and how these copathologies impact the clinical representation of these diseases.
Estrogen also led to lower levels of alpha-synuclein in the animals' brains.A
Masliah, "Beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor," Neuron, vol.
Ingelsson, "Alpha-synuclein oligomers--neurotoxic molecules in Parkinson's disease and other Lewy body disorders," Frontiers in Neuroscience, vol.
(a) Regions of interest, with ([MSA.sup.+], in red) and without ([MSA.sup.-], in white) aggregated alpha-synuclein staining were defined according to immunofluorescence ((A) MSA patient and (D) CTL subject).
Perhaps Corynebacterium in the GI tract induces expression of alpha-synuclein protein, a major component of PD Lewy bodies that's known to travel from the gut to the brain.
The researchers found that cardiolipin -- a molecule inside nerve cells -- helps ensure that a protein called alpha-synuclein folds properly.
One of the hallmarks of Parkinson's disease is an amyloid formation of a particular human protein, called alpha-synuclein. Alpha-synuclein is even sometimes referred to as the 'Parkinson's protein'.
Alpha-synuclein is a protein that is mis-folded and aggregates in PD, potentially driving disease progression.