alternative pathway


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Related to alternative pathway: classical pathway

alternative pathway

n. Immunology
The activation of complement by direct contact with polysaccharides located on the surface of bacteria or other pathogens. In contrast to the classical pathway, the alternative pathway is a nonspecific immune response that does not rely on the presence of antibodies.
References in periodicals archive ?
We all know how competitive entry to Graduate Entry Medicine can be, but Swansea can offer you an alternative pathway to your dream career through its undergraduate BSc programmes.
The results demonstrated that ACH-5228, when dosed 120 mg BID or higher, achieved near complete and sustained Alternative Pathway (AP) inhibition with a mean value of >95% at steady state concentrations as measured by AP Hemolysis and AP Wieslab assays.
The results demonstrated that ACH-5228, when dosed 120 mg BID or higher, achieved near complete and sustained Alternative Pathway inhibition with a mean value of greater than95% at steady state concentrations as measured by AP Hemolysis and AP Wieslab assays.
Omeros also has identified MASP-3 as the key activator of the human complement system's alternative pathway and as the enzyme responsible for the conversion of pro-factor D to factor D.
Summary: TEHRAN (FNA)- Scientists have harnessed liquid metals to turn carbon dioxide back into solid coal, in research that offers an alternative pathway for safely and permanently removing the greenhouse gas from our atmosphere.
Within CTE most states have more than one alternative pathway to receive teacher certification and there is a total of 105 alternative pathways and the average number of pathways per state is approximately two (Zirkle et al., 2007).
State flagship Indiana University Bloomington does not accept the alternative pathway.
If alternative pathway programs become incentivized at a national level, we must be prepared to challenge their negative impact using research on teacher preparation, teacher quality, and student learning.
As we know, there are three pathways to activate complement system in human body, including classic pathway, alternative pathway, and mannose-binding lectin pathway.
The alternative pathway of complement system activation [17] and oxidative stress [18] are also considered noteworthy participants in SLE pathogenesis.
Such an alternative pathway could open the door to the preparation of different cell types for cancer therapy.
Hemolytic activity in classical pathway and alternative pathway was associated with variation of the porcine genes encoding the complement components pC3 (Wimmers et al., 2003), the pC5 (Kumar et al., 2004), and the porcine mannose-binding lectin 1 (pMBL1) and pMBL2 (Phatsara et al., 2007).

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