alveolar proteinosis


Also found in: Medical, Wikipedia.
Translations

alveolar proteinosis

n proteinosis f alveolar
Mentioned in ?
References in periodicals archive ?
FDA approved its Investigational New Drug application for Molgradex, an inhaled formulation of recombinant human granulocyte-macrophage colony-stimulating factor, for the treatment of autoimmune pulmonary alveolar proteinosis, or PAP, allowing for the expansion of the company's Phase 3 IMPALA study into the U.
Pulmonary alveolar proteinosis (PAP): the presence of ground glass and/or consolidative infiltrates in patchy or diffuse distributions, reticular opacities or interlobular septal thickening present within the airspace infiltrates, creating a "crazy-paving" pattern on HRCT.
The combined company pipeline will include AeroVanc, an inhaled dry-powder vancomycin to treat chronic methicillin-resistant Staphylococcus aureus (MRSA) pulmonary infection in cystic fibrosis (CF) in preparation for a pivotal Phase 3 study, Molgradex, an inhaled nebulized GM-CSF to treat pulmonary alveolar proteinosis (PAP) currently in Phase 2/3 development and AIR001, an inhaled nebulised sodium nitrite solution to treat heart failure with preserved ejection fraction (HFpEF) currently in Phase two development.
sup][38] They used 2D-PAGE technology and compared the differential BALF proteome between normal volunteers and patients with pulmonary alveolar proteinosis.
Savara now has three product candidates, including AeroVanc, the first inhaled antibiotic being developed to address the growing problem of methicillin-resistant Staphylococcus aureus (MRSA) lung infection in people with cystic fibrosis, currently preparing for a Phase 3 trial, and Molgradex, an inhaled form of granulocyte-macrophage colony-stimulating factor (GM-CSF) currently in a Phase 2/3 clinical study to treat autoimmune pulmonary alveolar proteinosis.
In a case of pulmonary alveolar proteinosis CT was showing a crazy pavement pattern.
Pulmonary alveolar proteinosis (PAP) is a progressive lung disease characterized by accumulation of surfactant-like lipoproteinaceous material within the alveoli and distal bronchioles due to impaired clearance by alveolar macrophages.
Five patients with SFTP-C mutation had CIP, one patient had pulmonary alveolar proteinosis (PAP) and one patient hadfibrotic NSIP The histopathological diagnoses of the patients with ABCA3 mutation were as follows: PAP in four patients and DIP in two patients (12).
There are several diffuse lung diseases with pulmonary calcifications which might be included in the differential diagnosis of PAM such as pulmonary alveolar proteinosis, amyloidosis, metastatic pulmonary calcification, pulmonary vascular diseases, hyperparathyroidism, previous DNA virus infection, and chronic renal failure.
The text opens with an historical overview, followed by physiological and radiological features of common ILDs, such as idiopathic interstitial pneumonia, non-specific interstitial pneumonitis, and sarcoidosis, and uncommon ILDs, such as lymphangioleiomyomatosis, Langerhans cell granulomatosis, drug-induced lung disease, eosinophilic lung disease, alveolar proteinosis, and alveolar michrolithiasis.
Elevated levels of lung surfactant protein A in sera from patients with idiopathic pulmonary fibrosis and pulmonary alveolar proteinosis.
The 23-year-old was taken to Newcastle's Freeman Hospital at the end of 2009 with breathing difficulties and was eventually diagnosed with pulmonary alveolar proteinosis, a rare lung problem caused by the deficiency syndrome.