She was diagnosed with alveolar rhabdomyosarcoma
a rare, aggressive cancer that's typically found in the torso, arms and legs of young patients.
The differential diagnosis of MNTI includes other small round blue cell tumors of childhood, especially neuroblastoma, Ewing sarcoma, alveolar rhabdomyosarcoma
, and lymphoma, in addition to melanogenic tumors, including malignant melanoma and clear cell sarcoma of soft tissue.
Aaron Winstanley was diagnosed with alveolar rhabdomyosarcoma
in August 2016 after he developed sinus and congestion problems.
A 20-year-old man was referred to our institution from an oncological clinic where he was undergoing maintenance chemotherapy for metastatic alveolar rhabdomyosarcoma
. In routine EKG, there was concerning new EKG abnormalities with a possible new AV block.
Bittner et al., "Gene expression profiling of alveolar rhabdomyosarcoma
with cDNA microarrays," Cancer Research, vol.
Rebecca was just eight when she was first diagnosed with an extremely rare alveolar rhabdomyosarcoma
in February 2014 after going to hospital with a swelling in her leg.
Engel, "Vincristine, irinotecan, and temozolomide for treatment of relapsed alveolar rhabdomyosarcoma
," Journal of Pediatric Hematology/Oncology, vol.
Issakov et al., "Unusual leptomeningeal dissemination in a child with extracranial metastatic alveolar rhabdomyosarcoma
," Pediatric Hematology and Oncology, vol.
Barr, "Fusions involving PAX and FOX genes in the molecular pathogenesis of alveolar rhabdomyosarcoma
: recent advances," Current Molecular Medicine, vol.
(AR) is a very rare malignancy.
Embryonal Rhabdomyosarcoma (ERMS) occurs in 55% of patients; the Botryoid variant occurs in 5% of patients; Alveolar Rhabdomyosarcoma
(ARMS) occurs in 20% of patients and Undifferentiated Sarcoma (UDS) occurs in 20% of patients .