The Company presented data at the TCT meeting in February 2019 on the development candidate, an anti-CD117 amanitin
ADC, showing that it potently and selectively depleted hematopoietic stem cells in non-human primates while preserving the immune system.
An anti-CD117 ADC conjugated with amanitin
potently depleted human and non-human primate hematopoietic stem cells and progenitors in vivo.
Antibody Targeted Amanitin
Conjugates (ATACs), to improve efficiencies of ADCs.
Amatoxins, consisting of alpha, beta, and gamma amanitin
, account for >90% of deaths related to mushroom poisoning worldwide (1).
Many different drug models (e.g., those created using D-galactosamine, acetaminophen, carbon tetrachloride, amanitin
, concanavalin A, lipopolysaccharide, thioacetamide, and nitrosamines) have been described in the literature [18-23].
Amanita phalloides contains amanitin
, inhibiting RNA polymerase II.
poisoning is distinguished bythree clinical stages: an incubation stage, a gastrointestinal stage and a cytotoxic stage.
Its killer poison, amanitin
, damages the liver and kidneys.
arms and amanitin
, radioactive sustenance, high explosive, currency and mint, security printing and alcohol beverages.