We report the detection of influenza viruses A (H3N2) harboring a Q136K mutation in NA and an S31N mutation in M2, which respectively confer reductions in zanamivir and amantadine
The protocol calls for study participants to be randomized to receive either the TCAD therapy comprised of amantadine
and ribavirn with oseltamivir or oseltamivir monotherapy for 10 days.
is an anti-parkinsonian, antiviral agent that increases pre- and postsynaptic dopamine availability in the striatum.
All tested viruses retain their sensitivity to the other neuraminidase inhibitor, zanamivir, although the pandemic H1N1 strain is universally resistant to the adamantane antiviral medications, amantadine
The medicines range from the highly anticholinergic--such as tolterodine, Parkinson's disease drugs such as amantadine
(Symmetrel), the anti-reflux medication cimetidine (Tagamet) and allergy or sleep medications containing diphenhydramine (Benadryl)--to other drugs with weaker anticholinergic effects, including anti-reflux drugs such as ranitidine, the blood thinner warfarin (Coumadin) and the diuretics ("water pills") furosemide (Lasix) and hydrochlorothiazide.
This report describes the results of that survey, which indicated that 69.0% of the PCPs administered influenza tests to patients who had ILI during the influenza season and 53.8% prescribed antiviral agents, including two (i.e., amantadine
and rimantadine) no longer recommended by CDC.
This dietary supplement appeared to reduce MS patients' fatigue severity, and no such effect was seen with the more standard MS fatigue medication amantadine
in a small study.
Some four decades ago the M2 blocker, amantadine
(1-adamantanamine hydrochloride), was introduced to the market.
These factors, together with the routine use of antibiotics and Amantadine
(a human anti-flu drug) in feed, will ensure drug-resistant strains.
Although ion channel inhibitors, such as amantadine
, are effective against several strains of flu viruses, their side effects mean they are not being widely stockpiled, the experts said.
The company has also launched four products that are being marketed under its own label--dantrolene, the generic equivalent of Procter & Gamble Pharmaceuticals Inc.'s Dantrium; isradipine, the generic equivalent of Reliant Pharmaceuticals LLP's DynaCire; amantadine
, the generic version of Endo Pharmaceuticals' Symmetrel; and dipyridamole, the generic equivalent of Boehringer Ingelheim's Persantine.
Since the discovery of the anti-dyskinetic properties of amantadine
, there has been a renewed interest in its use.