Zemdri is an intravenous aminoglycoside
for the treatment of complicated urinary tract infections.
The Phase 3 EPIC clinical trial was the first multicenter, multinational, randomized, double-blind and controlled study of once-daily aminoglycoside
therapy for the treatment of cUTI, including acute pyelonephritis.
The treatment of choice for serious enterococcal infections is an aminoglycoside
in combination with a cell wall active agent.
Gentamicin is an aminoglycoside
antibiotic that has a broad spectrum of action against gram-negative bacterial infections and it is more recommended in severe cases (1).
- US-based Decibel Therapeutics has obtained an exclusive, worldwide license to the development and commercialisation of ORC-13661, an oral medication developed by Oricula Therapeutics for the prevention of hearing loss and balance disorders that can occur following treatment of severe infections with aminoglycoside
antibiotics, the companies said.
The present study aimed to investigate the occurrence of aminoglycoside
resistance and the prevalence of the resistance-modifying enzyme genes ant(3")-III, ant(6')-Ia, aac(6')-Ie-aph(2")-Ia, and aph(2')-Id in Enterococcus strains isolated from 2 hospitals in Kermanshah Province (Imam Khomeini and Imam Reza Kermanshah), west of Iran.
Twelve isolates (42.9%) were sensitive to gatifloxacin, tigeycycline and aminoglycoside
, while 28 isolates (100%) were sensitive to Carbapenem.
pneumoniae isolates to aminoglycoside
such as tobramycin (10 mg), gentamicin (10 mg), amikacin (30 mg) and kanamycin (5 mg) was performed using disk diffusion method (Kirby-Bauer) (Liofilchem, Italy) recommended by Clinical and Laboratory Standard Institute (CLSI) guideline (14).
Under the company's animal studies, ORC-13661 provided highly significant protection of hearing in rats exposed to high doses of aminoglycoside
antibiotics, a common cause of human hearing loss.
Enzymatic modification is the most common type of aminoglycoside
 Enterococci are resistant to a number of antimicrobial agents including [beta]-lactam antibiotics, glycopeptides and aminoglycosides
.  The emergence of multidrug resistant strains with high level aminoglycoside
resistance (HLAR), [beta]-lactamase production and glycopeptide resistance including vancomycin resistant enterococci (VRE) results in therapeutic failure, posing a serious threat to the life of patients.
The CDC said CREs resistant to all antimicrobials "are very uncommon," with 80 percent susceptible to at least one aminoglycoside
and nearly 90 percent susceptible to tigecycline.