aminopeptidase


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Related to aminopeptidase: leucine aminopeptidase

a·mi·no·pep·ti·dase

 (ə-mē′nō-pĕp′tĭ-dās′, -dāz′, ăm′ə-)
n.
Any of various enzymes that catalyze the hydrolysis of the terminal peptide bond of a polypeptide from the end that contains a free amino group.

aminopeptidase

(əˌmiːnəʊˈpɛptɪˌdeɪz)
n
an enzyme produced by the glands of the small intestine
References in periodicals archive ?
Quantum Genomics is a biopharmaceutical company specializing in the development of a new class of cardiovascular medications based on brain aminopeptidase A inhibition (BAPAI).
New York, NY, August 05, 2019 --(PR.com)-- Quantum Genomics are the creators of Firibastat, a first-in-class brain aminopeptidase inhibitor (BAPAI) that could potentially treat treatment-resistant hypertension by acting in the brain to interfere with the renin-angiotensin system.
(2009), using enzyme histochemistry, showed the importance of the intestinal mucosa as a site of action of digestive enzymatic activity of aminopeptidase M, dipeptidyl aminopeptidase IV, nonspecific esterase and alkaline and acid phosphatases from first feeding and throughout the larval development.
The sequence homology analysis indicated the high level identity of CELTN with M42 Family of aminopeptidases. Homology based on amino acid sequence of cellulase from present study indicated the Thermotoga maritima Tm-1049 as closest homologue with 98.5% identity whereas CELTN shared 36.5% identity with FrvX aminopeptidase from P.
In the current study we aim to determine whether Filamin 3 (FLNB) and aminopeptidase N (CD13), two of the eleven proteins previously identified in the secretome of senescent BM- and A-MSCs, could be involved in the key functions of senescent cells.
examined the effect of cinnamic acid on cell proliferation and the differentiation markers of alkaline phosphatase, sucrose and aminopeptidase N in human colon adenocarcinoma cells.
On chromosome 6 there are several protein coding sequences in near vicinity of the locus rs109210955, including leucine aminopeptidase (LAP3), mediator of RNA polymerase II transcription subunit 28 (MED28), family with sequence similarity 184 member B (FAM184B), DDB1 and CUL4 associated factor 16 (DCAF16), non-SMC condensin I complex subunit G (NCAPG), ligand-dependent nuclear receptor corepressor-like protein (LCORL).
Wedbush analyst Liana Moussatos initiated Zafgen with an Outperform rating and 12-month price target of $14, telling investors in a research note that she views Zafgen an opportunity to invest in a proprietary second generation methionine aminopeptidase 2 or MetAP2 inhibitor platform for treatment of complex metabolic disorders including difficult-to-control type-2 diabetes, Prader-Willi Syndrome and liver diseases like non-alcoholic steatohepatitis.
As described, TCs lacking wild-type or expressing mutant p53 had lower levels of transporter associated with antigen processing 1 (TAP1), endoplasmic reticulum aminopeptidase 1 (ERAP), Fas/APO-1, and miR-34 [Figure 1].[9] Among them, lower levels of TAP1 and lower concentration of ERAP1 resulted in limited expression of major histocompatibility complex I on TCs; subsequently, cytotoxic lymphocytes (CTLs) could inhibit the function of killing TCs and identify foreign proteins;[10] downregulation of Fas/APO-1 expression in TCs resulted in the reduction of CTL-mediated apoptosis on the binding of Fas-ligand (FasL) to Fas/APO-1.[11] Low levels of miR34 suppressed relative immune evasion of p53/miR-34/PD-L1 [Figure 1].{Figure 1}
Utility of malignancy markers in fine-needle aspiration cytology of thyroid nodules: comparison of Hector Battifora mesothelial antigen-1, thyroid peroxidase and dipeptidyl aminopeptidase IV Br J Cancer 2008; 98: 818-823.
This highly differentiated, polarized and in vivo like phenotype of the 3D model was further supported by the enhanced expression of brush border markers, e.g., glutamyltransferase 1 (GGT1), leucine aminopeptidase (LAP3) and alkaline phosphatase (ALPL) when compared to cells cultured under simpler conditions (Fig.
Seliger, "Aminopeptidase N (APN)/CD13-dependent CXCR4 downregulation is associated with diminished cell migration, proliferation and invasion," Molecular Membrane Biology, vol.