aminopterin


Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.

aminopterin

(ˌæmɪˈnɒptərɪn)
n
a derivative of pterin used in chemotherapy
Mentioned in ?
References in periodicals archive ?
Antimetabolites Aminopterin * + + / [+ or -] + Azathioprine 0 0 5-fluorouracil * + + + / + + + Methotrexate * + + / [+ or -] 0 Thioguanine + + No activity shown by cytarabine, mercaptopurine.
Sidney Farber, a pathologist at Boston Children's Hospital, was so distressed doing autopsies on these children that he moved into the clinic and, against the advice of more conservative colleagues, began treating children with aminopterin, a highly toxic drug that starved their cancerous white blood cells of critical nutrients.
Effect of aminopterin in rheumatoid arthritis and psoriasis.
He had also developed another version of antifolate -- aminopterin.
He had become aware of a report in the 1950s about the use of aminopterin (a folic acid antagonist) to induce therapeutic abortion; this had resulted in a high incidence of neural tube defects and anencephaly in the aborted fetuses.
The resulting cells were distributed into micro-well plates in hypoxanthine aminopterin thymidine medium which killed off the fusion partners, in that each well was left with one hybridoma cell.
Since then, it is believed that Aminopterin did not contribute to the deaths.
Less than a month later, on March 16, Menu Foods, an Ontario, Canada, manufacturer, announced a recall of 95 dog and cat food brands, all believed to contain aminopterin, a rodent poison banned in the United States that can cause kidney failure in pets.
The fused hybridoma cells were propagated in RPMI 1640 supplemented with 100 mL/L fetal bovine serum, hypoxanthine, aminopterin, and thymidine.
In utero exposure to aminopterin, an antagonist of folic acid, has been associated with anencephaly, meningocele, hydrocephalus, and cleft lip and palate (Thiersch 1952; Warkany et al.
sulfasalazine, methotrexate, triamterene, and aminopterin, that block conversion of folate to its more active metabolites, are known to cause NTDs.