aminopterin


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aminopterin

(ˌæmɪˈnɒptərɪn)
n
a derivative of pterin used in chemotherapy
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With the identification of the beneficial effects of aminopterin antimetabolite, chemotherapeutic agents known as disease-modifying anti-rheumatic drugs (DMARDs) were introduced to RA therapeutics in late 1980s.
To remove background mutants, MCL-5 cells were cultured for 3 days in R10 containing HAT [hypoxanthine, aminopterin, thymidine; Hybri-Max[TM] (Sigma-Aldrich, Poole, UK)], which is lethal to cells harboring mutations at the TK locus (Busby et al.
Antimetabolites Aminopterin * + + / [+ or -] + Azathioprine 0 0 5-fluorouracil * + + + / + + + Methotrexate * + + / [+ or -] 0 Thioguanine + + No activity shown by cytarabine, mercaptopurine.
Sidney Farber, a pathologist at Boston Children's Hospital, was so distressed doing autopsies on these children that he moved into the clinic and, against the advice of more conservative colleagues, began treating children with aminopterin, a highly toxic drug that starved their cancerous white blood cells of critical nutrients.
Los hibridos se cultivaron en medio de cultivo RPMI 1640 suplementado con medio Hypoxanthine Aminopterin Thymidine (HAT, Sigma, USA) como medio de seleccion metabolico.
Methotrxate and aminopterin are two uncommon antimetabolites that can induce cranial dysplasia and cleft palate in human.
Effect of aminopterin in rheumatoid arthritis and psoriasis.
He had also developed another version of antifolate -- aminopterin.
He had become aware of a report in the 1950s about the use of aminopterin (a folic acid antagonist) to induce therapeutic abortion; this had resulted in a high incidence of neural tube defects and anencephaly in the aborted fetuses.
There are several teratogenic agents and factors during pregnancy associated with formation of CLP, such as cortisone, anticonvulsants, salicylate, vitamin A, aminopterin, busalfan, organic solvents, maternal smoking, maternal hypoxia, maternal rubella, maternal diabetes mellitus, hypobaric hypoxia, and low social economical status.