Thus, clearance of substrates dependent upon microsomial function (i.e., aminopyrine
or caffeine) reflects functional reserve, while a substrate with high extraction (i.e., indocyanine green) depends mostly on blood flow [125, 126].
There were 8 (4.8%) cases caused by nonsteroidal antiinflammatory drugs (NSAIDs), including diclofenac, ibuprofen, analgin, and some compound which contained paracetamol, caffeine, and aspirin, or aminopyrine
, or phenacetin.
Agranulocytosis caused by Chinese herbal medicines: dangers of medications containing aminopyrine
After PB treatment, the activities of cytochrome p-450 (CP), aniline hydroxylase (AH), acetanilide hydroxylase (AAH), benzphatamine demethylase (BD), aminopyrine
demethylase (APD) and N.N dimethyl aniline demethylase (DAD) increased 214, 266, 207, 108, 81 and 83%, respectively.
It was found that buserelin (GnRH agonist) administration to rat males resulted in the decrease (in a dose-dependent manner) in the serum level of testosterone, and CYP450-dependent activity of aminopyrine
N-demethylase, 7-propoxycoumarin O-depropylase and testosterone 2[alpha]-hydroxylases and 16[alpha]-hydroxylases but not aniline p-hydroxylase .
Dose-dependent bone marrow supression is observed most commonly with chemotherapy drugs, phenothiazines, semi-synthetic penicillins, non-steroid anti-inflammatory drugs, aminopyrine
derivatives, barbiturates, gold compounds, sulfonamides and antithyroid drugs.
A number of pyrazolone derived compounds like antipyrine, dipyrone and aminopyrine
are the known drugs used to have analgesic and antipyretic activities and the pharmacological molecular mechanism of these drugs have been widely invaestigated [5,6].
GIV-A depressed aniline hydroxylase and aminopyrine
demethylase activities of the hepatic microsomal drug-metabolizing system in tumor-bearing mice.