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Related to aminopyrine: phenylbutazone


 (ə-mē′nō-pī′rēn′, ăm′ə-)
A colorless crystalline compound, C13H17N3O, formerly used to reduce fever and relieve pain, now known to cause agranulocytosis.

[amino- + (anti)pyrine.]


(əˌmaɪnəʊˈpaɪriːn; -ˌmiː-)
(Pharmacology) another name for aminophenazone
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.aminopyrine - a white crystalline substance used as an analgesic and antipyretic
analgesic, anodyne, pain pill, painkiller - a medicine used to relieve pain
References in periodicals archive ?
Thus, clearance of substrates dependent upon microsomial function (i.e., aminopyrine or caffeine) reflects functional reserve, while a substrate with high extraction (i.e., indocyanine green) depends mostly on blood flow [125, 126].
There were 8 (4.8%) cases caused by nonsteroidal antiinflammatory drugs (NSAIDs), including diclofenac, ibuprofen, analgin, and some compound which contained paracetamol, caffeine, and aspirin, or aminopyrine, or phenacetin.
Agranulocytosis caused by Chinese herbal medicines: dangers of medications containing aminopyrine and phenylbutazone.
After PB treatment, the activities of cytochrome p-450 (CP), aniline hydroxylase (AH), acetanilide hydroxylase (AAH), benzphatamine demethylase (BD), aminopyrine demethylase (APD) and N.N dimethyl aniline demethylase (DAD) increased 214, 266, 207, 108, 81 and 83%, respectively.
It was found that buserelin (GnRH agonist) administration to rat males resulted in the decrease (in a dose-dependent manner) in the serum level of testosterone, and CYP450-dependent activity of aminopyrine N-demethylase, 7-propoxycoumarin O-depropylase and testosterone 2[alpha]-hydroxylases and 16[alpha]-hydroxylases but not aniline p-hydroxylase [37].
Dose-dependent bone marrow supression is observed most commonly with chemotherapy drugs, phenothiazines, semi-synthetic penicillins, non-steroid anti-inflammatory drugs, aminopyrine derivatives, barbiturates, gold compounds, sulfonamides and antithyroid drugs.
A number of pyrazolone derived compounds like antipyrine, dipyrone and aminopyrine are the known drugs used to have analgesic and antipyretic activities and the pharmacological molecular mechanism of these drugs have been widely invaestigated [5,6].
GIV-A depressed aniline hydroxylase and aminopyrine demethylase activities of the hepatic microsomal drug-metabolizing system in tumor-bearing mice.