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Born with an extra copy of chromosome 21 which carries the gene for the amyloid precursor protein, Down syndrome patients show significantly increased amyloid in the brain and are at increased risk of developing Alzheimer's early in their lifetime.
announced its latest data of nonclinical research which examined the effect to the synaptic function in the brain by spinal densities(1) in regard to oral BACE (beta-site amyloid precursor protein cleaving enzyme) inhibitor elenbecestat(2) were presented at the Alzheimer's Association International Conference (AAIC) held in Los Angeles, California, United States, from July 14 to 18, 2019 (Poster Presentation No.: P2-064).
"Also, through the plasma proteomic and metabolomic studies in the Medalists, we found that there's this amyloid precursor protein or APP, that shows up as a potentially protective factor against diabetic kidney disease," Dr Shah added.
P-amyloid peptides are produced through endoproteolysis of the Amyloid Precursor Protein (APP) that is a large type-I transmembrane protein (9,10) .
The inflammatory environment triggers alteration in the nervous system and breaches the blood-brain barrier (BBB), thus inducing AD.[43] [sz] cleavage of amyloid precursor protein (APP) occurs in EEs to produce A[sz], which enters MVBs and is secreted into the extracellular space in the form of exosomes.[44] A[sz] can be transported by the exosomes to lysosome where it is degraded.
According to the company, it has initiated a MissionAD global Phase 3 trial for the Beta-site amyloid precursor protein cleaving enzyme (BACE) inhibitor elenbecestat (E2609) in China in partnership with Eisai Inc.
This model expresses mutant human amyloid precursor protein (APPSW) and presenilin 1(PS1?E9) genes which are each independent causes of early-onset familial AD.
Young et al., "Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein," Stem Cell Reports, 2018; DOI: 10.1016/j.stemcr.2018.01.031
* IL-1B, thought to increase amyloid precursor protein and promote tau phosphorylation, increased by 109%.
Namely, (1) amyloid [beta] (A[beta]40 and A[beta]42), which is produced by an abnormal cleavage of the amyloid precursor protein (APP) by [beta]- and [gamma]-secretase, is aggregated and accumulated extracellularly in cranial nerve cells.
Gradual accumulation of [beta]-amyloid peptide (A[beta]), the proteolitic product of amyloid precursor protein (APP), is the principal cause of synaptic dysfunction and cognitive loss in Alzheimer disease [1].