Glutamine can serve as an anaplerotic
mitochondrial fuel and seems to be important for tumor survival .
albicans downregulates glycolytic genes and upregulates glyoxylate cycle genes, which facilitate the assimilation of two carbon compounds with generation of anaplerotic
oxaloacetate to gluconeogenesis.
Significantly, inhibition of pyruvate oxidation stimulates anaplerotic
glutamine metabolism in human ESC , and glutamine-derived acetyl-CoA production in human cancer cells [86, 87], which are similarly increased in ESC .
roles of pyruvate carboxylase in mammalian tissues," Cellular and Molecular Life Sciences, vol.
That is, in addition to the classic [K.sub.ATP]-dependent mechanism, other mechanisms like anaplerotic
pathways maybe involved.
Kendrick, "Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic
products in insulin secretion," The American Journal of Physiology--Endocrinology and Metabolism, vol.
OBJECTIVE: The beneficial effect of the natural compound propionyl-l-carnitine (PLC) on intermittent claudication in patients with peripheral arterial disease is attributed to its anaplerotic
function in ischemic tissues, but inadequate information is available concerning action on the vasculature.
2), which contributes to 50% of the anaplerotic
flux of glutamate into the tricarboxylic acid (TCA) cycle.
The major regulatory effect of N[H.sub.3] released by AMPD is its contribution to fumarate to the tricarboxylic acid cycle (TCA) (anaplerotic
Experimental observation suggests that both anaplerotic
reactions and glyoxalate cycle play an important role for the production of tricarboxylic acid (TCA) cycle derived amino acids (aspartate which is a precursor of lysine and glutamate families) (Petersen, et al., 2001).
Cramer MD, Schierholt A, Wang YZ, Lips SH (1995) The influence of salinity on the utilization of root anaplerotic
carbon and nitrogen metabolism on tomato seedling.
This effect is most intriguing in light of recent observations demonstrating that the inhibition of electron transport in cancer cells is a lethal insult (39-41), not because of an ensuing energetic catastrophe--cancer cells derive most of their ATP from glycolysis, but because the accumulation of NADH in the mitochondrial matrix inhibits the Krebs cycle and its associated anaplerotic
reactions that support the generation of biomass (42).