Men with mosaic KS may be more androgenized
, with larger testicular volumes and better hormonal profiles, than their non-mosaic counterparts (21).
Polycystic ovary syndrome resembling histopathological alterations in ovaries from prenatal androgenized
ewes showed early increase in LH secretion, coupled with progressive loss in reproductive cyclicity and ovulatory failure , increased number of primary follicles , and persistent follicular cysts  along with upregulation of steroidogenic genes such as StAR, CYP11A, and CYP17 in thecal cells of female offspring .
Experiments using neonatally androgenized
female rats (the Barraclough PCOS model) indicated an altered pattern of hypothalamic luteinizing hormone-releasing hormone (LHRH) and pituitary LH/FSH contents directly related to changes in the pulsatile pattern of LH/FSH release .
Insights into the development of polycystic ovary syndrome (PCOS) from studies of prenatally androgenized
female rhesus monkeys.
Moenter, "Voluntary exercise improves estrous cyclicity in prenatally androgenized
female mice despite programming decreased voluntary exercise: implications for polycystic ovary syndrome (PCOS)," Endocrinology, vol.
Studies have shown that cryptotanshinone can reduce the levels of 17-OHP, the precursor of testosterone, in prenatally androgenized
male rats  and can reverse reproductive and metabolic disturbances in prenatally androgenized
female rats via regulation of CYP17 levels and other molecules in the insulin signaling pathway .
This first simile attempts to preserve a physical and psychical union between the two lovers, who are again undifferentiated by gender, androgenized
, within the single sheet of gold leaf.