In vitro androgen
receptor assays exploit the natural signaling pathway of androgens
and compounds that bind to the AR.
There are a few case series on castrated Ottoman court eunuchs, who, after 44 years, have small or non-palpable prostates on digital rectal examination, with evidence of atrophy on histological examination.[sup.1] It might suggest that the development and the viability of the gland throughout life require the continued presence of androgens
. After 8 months of anti-androgen or estrogen therapy, the histological appearance of the prostate reveals low content of malignant epithelial cells, which are only detectible by immunohisto-chemical staining.
are a group of hormones that play a role in male traits and reproductive activity.
* elevated androgens
evident in clinical presentation (hirstuism, acne, etc.) or upon laboratory findings
HER-2 has been proposed as a survival factor for prostate cells in the absence of androgens
, possibly by activating the androgen
Receptor (AR) gene plays an indispensable role in male fertility as it mediates the actions of androgens
Receptors have important roles both in the development of normal as well malignant prostate gland.15,28
KEYWORDS: Acne vulgaris, Androgens
, Hyperandrogenism, Acne Severity.
are necessary precursors of Oestrogen synthesis in the ovary.
It is widely accepted that androgens
are essential for the normal development and functional maintenance of male reproductive organs.
Hyperandrogenism refers to the condition in which excessive androgens
are found circulating in the female body.
The therapeutic effect of tanshinone in acne treatment is based on a reduction in testosterone levels , and the therapeutic effect in the case of excessive ovarian androgens
is also based on a reduction of testosterone levels .