Alzheimer's patients often experience damage to brain blood vessels caused by beta-amyloid proteins, an effect known as cerebral amyloid angiopathy
Supporting this findings, histological studies showed increased thickness of blood vessel basement membrane, reduction in collagen level of intercellular substance and signs of chronic inflammation and angiopathy
. This vascular problems can also cause anaerobic infection, which may be depend on reduced oxygen diffusion over the blood vessel wall (Bender & Bender).
, he said, was hall mark of connective tissue diseases.
It also helps to treat diabetic angiopathy
and diabetic retinopathy.
Diabetes has the potential to cause various complications due to angiopathy
Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy
. Proc Natl Acad Sci U S A.
In addition, protein oxidation has been shown, especially in myelin, elastin and collagen which may result in diabetic complications such as atherosclerosis, cataract, angiopathy
and nephropathy (33).
This correlation may be due to diffuse degeneration of brain tissue, atrophy of dentate nucleus, cranial nerve demyelination, and angiopathy
in individuals with long-term diabetes .
Diabetes mellitus (DM) has been recognized as the most common metabolic disorder that impairs blood glucose level which leads to high microvascular complications, angiopathy
, nephropathy, retinopathy, hepatopathy and neurological defects (Sharma et al., 2010; Khan et al., 2013).
is one of several conditions included in the spectrum of the Reversible Cerebral Vasoconstriction Syndromes (RCVS).18 Postpartum angiopathy
is characterised by severe headaches and reversible narrowing of intracerebral arteries, often complicated by seizures, reversible brain oedema, lobar haemorrhage, convexity (non-aneurysmal) subarachnoid haemorrhage and ischaemic strokes.
In our patient, because of the long history of diabetes and chronic wound, we looked for a solution to avoid diabetic angiopathy
complications and the probable complications linked to microsurgery, to spare the main vessels of the leg and to avoid long operating hours.