Alzheimer's patients often experience damage to brain blood vessels caused by beta-amyloid proteins, an effect known as cerebral amyloid
angiopathy (CAA).
Supporting this findings, histological studies showed increased thickness of blood vessel basement membrane, reduction in collagen level of intercellular substance and signs of chronic inflammation and
angiopathy. This vascular problems can also cause anaerobic infection, which may be depend on reduced oxygen diffusion over the blood vessel wall (Bender & Bender).
Micro
angiopathy, he said, was hall mark of connective tissue diseases.
It also helps to treat diabetic
angiopathy and diabetic retinopathy.
Diabetes has the potential to cause various complications due to
angiopathy and neuropathy.
Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic
angiopathy. Proc Natl Acad Sci U S A.
In addition, protein oxidation has been shown, especially in myelin, elastin and collagen which may result in diabetic complications such as atherosclerosis, cataract,
angiopathy and nephropathy (33).
This correlation may be due to diffuse degeneration of brain tissue, atrophy of dentate nucleus, cranial nerve demyelination, and
angiopathy in individuals with long-term diabetes [18].
Diabetes mellitus (DM) has been recognized as the most common metabolic disorder that impairs blood glucose level which leads to high microvascular complications,
angiopathy, nephropathy, retinopathy, hepatopathy and neurological defects (Sharma et al., 2010; Khan et al., 2013).
Postpartum
angiopathy is one of several conditions included in the spectrum of the Reversible Cerebral Vasoconstriction Syndromes (RCVS).18 Postpartum
angiopathy is characterised by severe headaches and reversible narrowing of intracerebral arteries, often complicated by seizures, reversible brain oedema, lobar haemorrhage, convexity (non-aneurysmal) subarachnoid haemorrhage and ischaemic strokes.
In our patient, because of the long history of diabetes and chronic wound, we looked for a solution to avoid diabetic
angiopathy complications and the probable complications linked to microsurgery, to spare the main vessels of the leg and to avoid long operating hours.
angiopathy - any disease of the blood vessels or lymph ducts