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Related to angiostatin: endostatin


A naturally occurring protein with potent antiangiogenic properties that is formed from the cleavage of plasminogen and has been investigated for use in cancer treatment.

References in periodicals archive ?
Angiostatin inhibits coronary angiogenesis during impaired production of nitric oxide.
Oppositely, macrophage elastase produced by tumor-associated macrophages cleaves plasminogen, thrombospondin, and type XVIII collagen generating anti-angiogenic molecules, such as angiostatin, thrombospondin fragments, and endostatin, respectively.
Likewise, PLG is activated by proteolysis and converted to plasmin and angiostatin which inhibit angiogenesis through diminishing activation of mitogen-activated protein kinases (Redlitz et al.
Kolata reported on the findings of Judah Folkman, of Boston Children's Hospital, whose 30 years of work led to the discovery of angiostatin and endostatin.
In addition, MMPs may be responsible for the generation of natural angiostatic substances such as angiostatin, which inhibits vascular endothelial cell proliferation and is the proteolytic product of plasminogen (16).
N-acetyl-cysteine promotes angiostatin production and vascular collapse in an orthotopic model of breast cancer.
Angiostatin is a naturally occurring product of the PAS from the cleavage of plasminogen with strong inhibitory effects on blood vessel formation in vivo (Jing et al- 2004).
Chronic hyperglycemia attenuates coronary collateral development and impairs proliferative properties of myocardial interstitial fluid by production of angiostatin.
Yuan et al reported increased expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and decreased expression of angiostatin and thrombospondin-1 in pyogenic granuloma tissue compared to healthy gingiva and gingiva affected by periodontitis.
Therapeutic potential of angiostatin in diabetic nephropathy.
Also, angiostatin (angiogenesis inhibitor) was expressed significantly less in pyogenic granulomas than in healthy gingiva and periodontal inflammation.
Antiangiogenic peptides, such as angiostatin, are of major interest in the field of cancer research.