angiostatin


Also found in: Medical, Wikipedia.
Related to angiostatin: endostatin

an·gi·o·stat·in

 (ăn′jē-ō-stăt′n)
n.
A naturally occurring protein with potent antiangiogenic properties that is formed from the cleavage of plasminogen and has been investigated for use in cancer treatment.

References in periodicals archive ?
Likewise, PLG is activated by proteolysis and converted to plasmin and angiostatin which inhibit angiogenesis through diminishing activation of mitogen-activated protein kinases (Redlitz et al.
N-acetyl-cysteine promotes angiostatin production and vascular collapse in an orthotopic model of breast cancer.
Successful retinal transduction, as shown by substantial increase in expression and secretion of endostatin and angiostatin proteins measured in the anterior chamber of the eye following a single administration of RetinoStat[sup.
Angiostatin is a naturally occurring product of the PAS from the cleavage of plasminogen with strong inhibitory effects on blood vessel formation in vivo (Jing et al- 2004).
Yuan et al reported increased expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and decreased expression of angiostatin and thrombospondin-1 in pyogenic granuloma tissue compared to healthy gingiva and gingiva affected by periodontitis.
Therapeutic potential of angiostatin in diabetic nephropathy.
Also, angiostatin (angiogenesis inhibitor) was expressed significantly less in pyogenic granulomas than in healthy gingiva and periodontal inflammation.
Antiangiogenic peptides, such as angiostatin, are of major interest in the field of cancer research.
The article concerned two new agents, endostatin and angiostatin, developed by Harvard Professor judah Folkman, MD.
Some inhibitors are platelet and plasma-derived such as angiostatin, endostatin, and platelet factor-4 (Daly et al.
Generation of biologically active angiostatin kringle 1-3 by activated human neutrophils.
Two proteins, angiostatin and endostatin, have been shown to possess anti-angiogenic activity.