inhibits coronary angiogenesis during impaired production of nitric oxide.
Oppositely, macrophage elastase produced by tumor-associated macrophages cleaves plasminogen, thrombospondin, and type XVIII collagen generating anti-angiogenic molecules, such as angiostatin
, thrombospondin fragments, and endostatin, respectively.
Likewise, PLG is activated by proteolysis and converted to plasmin and angiostatin
which inhibit angiogenesis through diminishing activation of mitogen-activated protein kinases (Redlitz et al.
Kolata reported on the findings of Judah Folkman, of Boston Children's Hospital, whose 30 years of work led to the discovery of angiostatin
In addition, MMPs may be responsible for the generation of natural angiostatic substances such as angiostatin
, which inhibits vascular endothelial cell proliferation and is the proteolytic product of plasminogen (16).
N-acetyl-cysteine promotes angiostatin
production and vascular collapse in an orthotopic model of breast cancer.
is a naturally occurring product of the PAS from the cleavage of plasminogen with strong inhibitory effects on blood vessel formation in vivo (Jing et al- 2004).
Chronic hyperglycemia attenuates coronary collateral development and impairs proliferative properties of myocardial interstitial fluid by production of angiostatin
Yuan et al reported increased expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and decreased expression of angiostatin
and thrombospondin-1 in pyogenic granuloma tissue compared to healthy gingiva and gingiva affected by periodontitis.
Therapeutic potential of angiostatin
in diabetic nephropathy.
(angiogenesis inhibitor) was expressed significantly less in pyogenic granulomas than in healthy gingiva and periodontal inflammation.
Antiangiogenic peptides, such as angiostatin
, are of major interest in the field of cancer research.