is the physiologically active product of RAS, and it works not only as a strong vasopressor but also as a promoter of tissue remodeling in various organs such as heart, arteries and kidneys.
In a study published in the New England Journal of Medicine, researchers note that for critically ill patients, treatment with synthetic angiotensin II
can help control dangerously low blood pressure.
Gestational therapy with an angiotensin II
receptor antagonist and transient renalfeature in premature infant.
The report provides comprehensive information on the Type-2 Angiotensin II
Receptor (Angiotensin II
Type-2 Receptor or AT2 or AGTR2), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Supply Angiotensin II
antagonists for hypertension.
Serine phosphorylation sites on IRS2 activated by angiotensin II
and protein kinase C to induce selective insulin resistance in endothelial cells," Molecular and Cellular Biology, vol.
Sraer, "Pivotal role of the renin/prorenin receptor in angiotensin II
production and cellular responses to renin," The Journal of Clinical Investigation, vol.
For each experiment, the cells were cultivated for the indicated period in EGM-2 medium in presence of human angiotensin II
(Sigma) at a concentration 1.
ACE inhibitors act by reducing the biosynthesis of angiotensin II
by blocking the conversion of angiotensin I by ACE, but do not inhibit non-ACE angiotensin II
, at the three different concentrations tested (10[micro]M, 0.
Numerous compounds which inhibit renin, ACE, and the angiotensin II
receptor have been used in the treatment of high blood pressure for the last 30 years.
Human aortic endothelial cells (HAECs) were stimulated by angiotensin II
(Ang II, 100 nmol/L) with or without pretreatment of valsartan (100 nmol/L), and relative expression of cyclooxygenase-2 (COX-2) and thromboxane B [sub]2 (TXB [sub]2 ) and both p38 mitogen-activated protein kinase (p38MAPK) and nuclear factor-kB (NF-kB) activities were assessed.