Prophylactic treatment of migraine with an angiotensin II receptor blocker
: a randomized controlled trial.
Because of their proven clinical benefits, drugs that act on the renin-angiotensin system (RAS) such as angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin II receptor blockers
(ARBs) have become the first-line therapy for many patients with cardiovascular conditions.
43 Men/women 25/18 Age (years) 66.1 [+ or -] 1.71 BMI (kg/[m.sup.2]) 24.8 [+ or -] 0.5 Treatment duration of T2D (years) 7.1 [+ or -] 1.18 Medications ARB 23 (53.5%) [alpha]-GI 8 (18.6%) TZD 5 (11.6%) ARB: angiotensin II receptor blockers
, [alpha]-GI: [alpha]-glucosidase inhibitors, and TZD: thiazolidines.
It is the first and only fixed-dose combination (FDC) of a beta blocker (BB) and angiotensin II receptor blocker
(ARB) available in the US.
STOCKHOLM -- Stand-alone angiotensin II receptor blocker
therapy proved of no benefit in preventing recurrences of paroxysmal atrial fibrillation in patients without structural heart disease in a large German randomized double-blind trial.
Tokyo, Japan, July 5, 2006 - (JCN) - Astellas Pharma and Nippon Boehringer Ingelheim have filed a joint application for an additional indication of Micardis, an angiotensin II receptor blocker
, with the Ministry of Health, Labor and Welfare.
Avapro is an angiotensin II receptor blocker
originally approved by the FDA in 1997 for use in treating hypertension.
Cozaar is an angiotensin II receptor blocker
Micardis is an angiotensin II receptor blocker
, indicated to treat hypertension, to decrease blood pressure and cardiovascular risk reduction in patients unable to take ACE inhibitors.
Standard background therapy in both study arms included diuretics, ACE inhibitor or angiotensin II receptor blocker
therapy, a beta-blocker, and an aldosterone antagonist.
Olmesartan is an angiotensin II receptor blocker
(ARB), marketed as Benicar by Daiichi Sankyo Inc.
Could an angiotensin II receptor blocker
(ARB) such as telmisartan (Micardis) be a useful alternative?