is involved in adipose tissue growth and blood pressure regulation.
ALN-AGT is an investigational, subcutaneously administered RNAi therapeutic targeting angiotensinogen
in development for the treatment of hypertension in high unmet need populations.
A1166C variant of angiotensin II type 1 receptor gene is associated with severe hypertension in pregnancy independently of T235 variant of angiotensinogen
The renin-dependent catabolism of angiotensinogen
is the rate-limiting step in the RAS cascade (6).
Haynes et al., "Adipose depot-specific modulation of angiotensinogen
gene expression in diet-induced obesity," American Journal of Physiology, Endocrine and Metabolism, vol.
Sigmund, "Genetic basis of hypertension: revisiting angiotensinogen
," Hypertension, vol.
is the only known substrate for renin.
Renin is an aspartyl protease glycoprotein enzyme that catalyses the restrictive excision of the angiotensinogen
(AGT) to angiotensin I (Ang I), an essential component within the processes of the system's activation .
Li, "Mechanisms for inducible control of angiotensinogen
gene transcription," Hypertension, vol.
and angiotensin converting enzyme gene polymorphisms and the risk of bipolar affective disorder in humans.
Renin acts enzymatically on the plasma protein, angiotensinogen
, which is converted to angiotensin I, a mild vasoconstrictor.
Although there are a number of potent hormonal triggers controlling kidney output, such as angiotensinogen
, aldosterone and atrial natruretic peptide, the 'final and precise regulation of water balance is dependent on thirst and on Anti-Diuretic Hormone (ADH) release' as stimulated by the osmoreceptors in the hypothalamus.