Beside these peripheral metabolic effects, adiponectin receptors are also expressed widely in the brain and recent reports indicate that hypothalamic adiponectin-receptor complex is probably involved in the control of food intake, effected by anorexigenic
leptin and insulin, and conversely stimulated by orexigenic ghrelin.16,17 We also think in this study the relatively higher adiponectin and lower ghrelin levels measured during Ramadan fasting could be related to increased sense of hunger.
The present study was designed to investigate the in vivo effect of an anorexigenic
gut peptide obestatin on plasma testosterone and prolactin secretion, in adult male Sprauge Dawley rats.
Furthermore, in anaesthetized dogs, cathinone had cardiovascular effects comparable to amphetamine (Kohli & Goldberg 1982), and anorexigenic
effects in rats (Zelger & Carlini 1980).
"Our unique genetic mouse models have revealed that POMC neurons are physiologically important targets of potent anorexigenic
5-HT compounds such as d-fenfluramine to suppress appetite," said Elmquist.
Shanabrough et al., "Enhanced anorexigenic
signaling in lean obesity resistance syndecan-3 null mice," Neuroscience, vol.
GLP-1 is an anorexigenic
and glucoregulatory hormone secreted by the intestinal L cells and by the nucleus tractus solitarius of the brainstem.
Oxytocin is an anorexigenic
neuropeptide that controls metabolic homeostasis not only via an effect on food intake but also by modulating energy expenditure (15).
It was first described as a satiety- and appetite-regulating hormone that induces a decrease of food intake, stimulating the hypothalamus inducing anorexigenic
factors and suppressing orexigenic factors evoking the feeling of satiety, but also stimulates thermogenesis and energy expenditure by lowering blood glucose levels [29, 30].
response is mediated by proopiomelanocortin (POMC) neurons, and the orexigenic response is mediated by agouti-related protein (AgRP) expressing neurons .
Additionally, IFT88[DELTA]/[DELTA] mice responded to the anorexigenic
effect of leptin, an indication that the leptin response remains intact after the depletion of the protein IFT88 and, therefore, the loss of the PC in preobese mice.
The neuropeptides concerned with feeding behavior are involved in this complex controlling system, of which the anorexigenic
neuropeptide like proopiomelanocortin (POMC) and orexigenic neuropeptide like Neuropeptide Y (NPY) play important roles in the regulation of food intake and energy balance (Bazhan and Zelena, 2013).