Spironolactone is an androgen receptor and 5a-reductase blocker, and its antiandrogen
effects can improve acne.
KEY WORDS: antiandrogen
, AR-Lux, biomonitoring, endocrine disruption, fungicide.
The third topical agent is a potent antiandrogen
called CB-03-01 (cortexolone 17[alpha]-propionate 1%).
2005) and suppressions of androgen synthesis have been associated with antiandrogen
exposure in humans (Main et al.
-- A once-daily dosage of the nonsteroidal antiandrogen
bicalutamide decreased the risk of prostate cancer progression by 57%, Dr.
NEW YORK -- Antiandrogen
hormones can help stabilize, and even improve, female pattern hair loss.
In evaluating different HT regimens, the investigators included in the progestin category drugs that are not progestins such as cyproterone acetate, an antiandrogen
, and raloxifene, a selective estrogen receptor modulator (SERM).
Eplerenone, a newer spironolactone without the antiandrogen
effects, may be a better therapy but also lacks clinical data.
topical retinoid [+ or -] BP/Dapsone Alternatives Oral antiandrogen
* Oral antiandrogen
for Females + topical retinoid/ ([dagger]) ([double dagger]) dapsone + topical retinoid ([section]) [+ or -] topical + oral antibiotic antimicrobial [+ or -] topical antimicrobial Maintenance Therapy Topical retinoid [+ or -] BP Acne Severity Severe Nodular/Conglobate 1st Choice Oral isotretinoin Alternatives High dose ([double dagger]) oral antibiotic + topical retinoid + BP Alternatives High dose oral for Females antiandrogen
* ([double dagger]) + topical retinoid ([section]) + alt.
It is a reliable marker of androgen and antiandrogen
effects in rodent reproductive toxicologic studies.
therapy is required to prevent this brief testosterone "surge," and subsequent tumor growth, the FDA said.
The one exception was with the weakest antiandrogen
, linuron, in a laboratory with reduced sensitivity because of high coefficients of variation in all tissue weights.