These include antiangiogenic
agents, immunotherapy, bacterial agents, viral oncolysis, targeting of cyclic-dependent kinases and tyrosine kinase receptors, antisense approaches, gene therapy and combination of various methods.
Featured presentations include: -- Impact of Endothelia Progenitor cells in antiangiogenic
drug mediated chemosensitization -- SUTENT (Sunitinib), a multi-targeted RTKI, phase 3 results in advanced RCC and GIST -- Normalization of tumor vasculature and microenvironment by antiangiogenic
therapies -- Inhibition of tumor angiogenesis and growth using novel antagonist of Id1
Vice President of Pharmaceutical Services, was previously the Director of Research at the Carilion Biomedical Institute, where he was responsible for managing the research funding that led to the discovery of the small antiangiogenic
molecules utilized by OcuCure.
Panzem(R) (2ME2) is an orally-active small molecule that attacks tumor cells through multiple mechanisms of action and has antiangiogenic
NASDAQ: OXGN, XSSE: OXGN) today announced that the first patient has been enrolled and dosed in its Phase Ib clinical trial in advanced solid tumors, which combines its lead Vascular Disrupting Agent (VDA), CA4P, with an antiangiogenic
agent, bevacizumab (Avastin).
Analogs of 2ME2 have been developed by EntreMed to decrease metabolism while retaining their antiproliferative and antiangiogenic
AMG 706 is an oral, highly selective inhibitor of the VEGF pathway, targeting all of the VEGF receptors that demonstrate both antiangiogenic
and direct antitumor activity (including inhibition of Platelet Derived Growth Factor receptor and Kit, two proteins involved in the regulation of cell proliferation).
VLDL Receptor Binding Peptides Demonstrate Antiangiogenic
In addition, recent preclinical work has demonstrated that combining vasculature disrupting agents and traditional antiangiogenic
agents may result in better efficacy than either one alone.
The increase in volume of drug per patient will likely arise from the introduction of novel immunotherapeutic and antiangiogenic
agents administered concurrently with or following treatment with the current gold-standard therapy of carboplatin (Bristol-Myers Squibb's Paraplatin, generics) combined with paclitaxel (Bristol-Myers Squibb's Taxol, generics)," said Jude Nelson, analyst at Decision Resources, Inc.
NASDAQ: OXGN, XSSE: OXGN) today announced the publication of the results of a preclinical study evaluating the combination of vascular disrupting agents (VDAs) with an antiangiogenic
drug to enhance suppression of tumor growth in mice, which appears in today's issue of the journal Science.
The company has developed expertise in a wide range of cancer therapies, including cytotoxics, cytostatics, monoclonal antibodies, cell-based therapies, vaccines, antiangiogenic
agents, apoptosis inducers and hormonal therapies.