Several complexes with different metals such as Pt, As, Au, Co, Tc, Gd, are approved by FDA and they are used as therapeutic, anticancer, antisyphillis, antiarthritic
, antimicrobial and diagnostic agent, in single photon emission computed tomography respectively .
precatorius seeds are also reported to have anticancer, (19) antifertility, (4) antitumor, antispermatogenic, antibacterial, (20,21) antidiabetic, (22) antioxidant, (23) nephroprotective, (24) antiarthritic
, (25) antimicrobial, (19) and antimalarial activities.
The PG fruit and leaves have high antioxidant, antimicrobial, liver protective, antiplaque, anticancer, analgesic, anti-inflammatory, immune-system-regulating and antiarthritic
Fisetin has been documented to have antioxidant, anticarcinogenic, antiulcer, anticonvulsant, anti-hyperlipidemic, antiarthritic
, antidiabetic, antimicrobial, antiviral, cardioprotective, and neuroprotective properties.16-22 Recently, researchers have also reported the antiasthmatic potential of fisetin against OVA-induced airway hyperresponsiveness via inhibition of lgG, lgE, iNOS, TNF-[alpha], IL-4, IL-5, IL-13, and NF-kB.19,23 As immune-inflammatory reactions like AR and asthma are two closely related disorders of airway disease, almost 88% of asthma patients have suffered from the symptoms of AR as well.24 Moreover, the animal models of both the allergic inflammation diseases are produced similarly.24
It has been widely used by folk medicine as an anticancer, antioxidant, antibacterial, anti-inflammatory, antifertility, antiarthritic
, cardioprotective, larvicidal, antimutagenic/genoprotective, antidepressant, etc., and also has been extensively used in Ayurveda, Unani, and Homeopathy practices.
Rutin possesses several pharmacological activities such as reducing oxidative stress, prevent neuroinflammation (7), anti-diabetic (8), aiding to reduce neurodegeneration (9), cardioprotective activity (10), wound healing activity (11), radioprotective activity (12,13), nephroprotective activity (14), hepatoprotective activity (15), antiplasmodial activity (16), antiarthritic
activity (17), antiviral activity (18), improved endothelial functions (19) and antinociceptive activities (20).
In addition, the author evaluated the biosynthesized ZnO nanoparticles for antidandruff, antimicrobial, and antiarthritic
FR[beta] is also of interest from a therapeutic perspective as it can bind and internalize antifolates and folate-conjugated antiarthritic
These have different bioactivities such as antimicrobial mussel peptides or anti-inflammatory, antiarthritic
, and anticancer agents [4, 5].
Curcumin, in particular, the primary active ingredient of turmeric (Curcuma longa), has been demonstrated to possess anti-inflammatory, antiosteoclastogenic potential, and antiarthritic
Secondly, in the current study, longitudinal changes in the levels of immune semaphorins were not available and we could not examine whether their levels were significantly altered with antiarthritic
Moreover, CD39 blockade dampened the antiarthritic
effect of MTX treatment in a murine model of RA, thus suggesting that CD39 and ADO production is involved in the mechanism of action of MTX and is required for the responsiveness to the treatment.