Long-term antiepileptic drug
therapy contributes to the acceleration of atherosclerosis.
company UCB reported on Friday the receipt of approval from the US Food and Drug Administration (FDA) for its supplemental new drug application (sNDA) for BRIVIACT (brivaracetam) CV as monotherapy for partial-onset (focal) seizures (POS) in patients 16 years and older with epilepsy.
According to the company, BRIVIACT is the newest antiepileptic drug
(AED) in the 'racetam' class of medicines and demonstrates a high and selective affinity for synaptic vesicle protein 2A (SV2A) in the brain, which may contribute to its anticonvulsant effects.
Despite these limitations, the results are notable because they represent the only data set yet reported from a community-based source large enough to allow analysis of the many clinical variables that play into the potential interactions between various contraceptive types, various antiepileptic drug
classes, and the diverse number of epilepsy subtypes, he said.
Different profiles of antiepileptic drug
therapy (Mean dose, mean duration of therapy, drug levels and incidence of adverse effects) are shown in Table 3.
Fycompa is a first-in-class antiepileptic drug
discovered and developed by Eisai.
Early child development and exposure to antiepileptic drugs
prenatally and through breastfeeding: a prospective cohort study on children of women with epilepsy.
Valproic acid (VPA), a broad-spectrum antiepileptic drug
, has been used in therapy for epilepsy since 1967.
Patients in the study who withdrew from antiepileptic drug
(AED) treatment were not significantly more likely to have seizure recurrence than were those who did not, thereby meeting the common secondary goal of discontinuing or reducing AEDs after epilepsy surgery Thus, the findings of this study may provide reassurance to neurologists who are hesitant to withdraw AEDs after surgery because of concerns that seizures may recur, Dr.
Fetal antiepileptic drug
exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study.
The FDA cited data from the Neurodevelopmental Effects of Antiepileptic Drugs
study, published in March 2013, which found that at age 6, children whose mothers had taken valproate products while pregnant had lower IQs, compared with those whose mothers took other antiepileptic drugs
14] Takahashi A, Onodera K, Kamei J, Sakurada S, Shinoda H, Miyazaki S, Saito T, Mayanagi H, Effects of chronic administration of zonisamide, an antiepileptic drug
, on bone mineral density and their prevention with alfacalcidol in growing rats, J Pharmacol Sci, 2003; 91(4)713-318.