Based on a clinical trial, the risk of her cancer returning is significantly less if we combine ovarian suppression and an antiestrogen
hormonal therapy compared to antiestrogen
hormonal therapy alone."
Design, synthesis and evaluation of antiestrogen
and histone deacetylase inhibitor molecular hybrids.
All cases received pre-or postoperative chemotherapy [+ or -] antiestrogen
therapy and, in locally advanced stages, palliative external radiotherapy.
Estrogen and antiestrogen
regulation of cell cycle progression in breast cancer cells.
This is regardless of postoperative antiestrogen
Beyond surgery, multiple additional therapies have been tested, such as hormonal therapy with antiestrogen
agents or gonadotropin agonists, sclerotherapy with tetracycline, potassium-titanyl-phosphate laser, and hyperthermic intraperitoneal chemotherapy (HIPEC) [2, 6, 7, 34].
Hess, "Infertility and testicular atrophy in the antiestrogen
treated adult male rat," Biology of Reproduction, vol.
Shiu, "C-myc gene expression alone is sufficient to confer resistance to antiestrogen
in human breast cancer cells," International Journal of Cancer, vol.
Estrogen control of progesterone receptor in human breast cancer: role of estradiol and antiestrogen
. Endocrinology 1978; 103: 1742-51.
Given her critical illness and patient's desire for a less aggressive palliative approach, the patient elected for antiestrogen
therapy with Fulvestrant over a trial of single-agent chemotherapy.
The product is a prescription medicine used to treat hormone receptor-positive metastatic breast cancer in women who have gone through menopause whose disease has spread following treatment with antiestrogen
Being female is also reported as a risk factor, and there may be a link between antiestrogen
therapy and ABRT-ONJ (Vaszilko et al., 2014).