antagonist

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antagonist

a person who opposes another, often in a hostile manner: The man was his antagonist in a duel.; an enemy, foe; the adversary of the hero or protagonist in a literary work
Not to be confused with:
adversary – a person, group, or force that opposes or attacks; opponent; enemy; foe; one who is an opponent in a contest; a contestant; one who fights determinedly and relentlessly: He was a worthy adversary.
adversity – catastrophe, disaster; trouble, misery; adverse fortune or fate; a condition marked by misfortune: In times of adversity, she crumbles.

an·tag·o·nist

 (ăn-tăg′ə-nĭst)
n.
1. One who opposes and contends against another; an adversary.
2. The principal character in opposition to the protagonist or hero of a narrative or drama.
3. Physiology A muscle that counteracts the action of another muscle, the agonist.
4. A drug or chemical substance that interferes with the physiological action of another, especially by combining with and blocking its receptor.

an·tag′o·nis′tic adj.
an·tag′o·nis′ti·cal·ly adv.

antagonist

(ænˈtæɡənɪst)
n
1. an opponent or adversary, as in a contest, drama, sporting event, etc
2. (Physiology) any muscle that opposes the action of another. Compare agonist1
3. (Pharmacology) a drug that counteracts the effects of another drug. Compare synergist1

an•tag•o•nist

(ænˈtæg ə nɪst)

n.
1. a person who is opposed to or competes with another; opponent; adversary.
2. (in drama or literature) the opponent of the hero or protagonist.
3. a muscle that acts in opposition to another. Compare agonist (def. 3).
4. a tooth in one jaw that articulates with a tooth in the other jaw.
5. a drug that counteracts the effects of another drug.
[1590–1600; < Late Latin < Greek]

an·tag·o·nist

(ăn-tăg′ə-nĭst)
A muscle that resists or counteracts another muscle, as by relaxing while the opposite one contracts. Compare agonist.

antagonist

an opponent in any kind of contest or conflict. Also called antipathist.
See also: Conflict
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.antagonist - someone who offers oppositionantagonist - someone who offers opposition  
individual, mortal, person, somebody, someone, soul - a human being; "there was too much for one person to do"
dueler, duelist, dueller, duellist - a person who fights duels
foe, foeman, enemy, opposition - an armed adversary (especially a member of an opposing military force); "a soldier must be prepared to kill his enemies"
Luddite - any opponent of technological progress
withstander - an opponent who resists with force or resolution; "obstinate withstanders of innovation"
agonist - someone involved in a contest or battle (as in an agon)
2.antagonist - a muscle that relaxes while another contractsantagonist - a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
antagonistic muscle - (physiology) a muscle that opposes the action of another; "the biceps and triceps are antagonistic muscles"
3.antagonist - a drug that neutralizes or counteracts the effects of another drug
drug - a substance that is used as a medicine or narcotic
estrogen antagonist, tamoxifen - an antagonist for estrogen that is used in the treatment of breast cancer
narcotic antagonist - an antagonist used to counteract the effects of narcotics (especially to counteract the depression of respiration)
synergist - a drug that augments the activity of another drug

antagonist

noun opponent, rival, opposer, enemy, competitor, contender, foe, adversary He had never previously lost to his antagonist.

antagonist

noun
One that opposes another in a battle, contest, controversy, or debate:
Translations
خَصْم، مُعارِض
odpůrceprotivníksoupeř
modstander
andstæîingur
antagonizmassukelti priešiškumą
pretinieks

antagonist

[ænˈtægənɪst] Nantagonista mf, adversario/a m/f

antagonist

[ænˈtægənɪst] n (= opponent, enemy) → antagoniste mf, adversaire mf

antagonist

nKontrahent(in) m(f), → Gegner(in) m(f), → Antagonist(in) m(f); (esp Pol) → Gegenspieler(in) m(f)

antagonist

[ænˈtægənɪst] nantagonista m/f

antagonist

(ӕnˈtӕgənist) noun
an opponent or enemy.
anˈtagonism noun
unfriendliness, hostility.
anˌtagoˈnistic adjective
anˌtagoˈnistically adverb
anˈtagonize, anˈtagonise verb
to make an enemy of (someone). You are antagonizing her by your rudeness.

an·tag·o·nist

a. antagonista, droga que neutraliza los efectos de otra.

antagonist

n antagonista m; calcium — antagonista del calcio; CCR5 — antagonista del CCR5
References in periodicals archive ?
[7] Another antifolate agent raltitrexed that has similar efficacy to pemetrexed can also be considered to reduce the cost related to treatment.
Antibiotic therapy is the most common for treating the UTIs during gestation, Trimethoprim Sulfamethoxazole (TMP-SMX) is one of antifolate used in such therapies.
In February 1948, Sidney Farber, a pathologist at Harvard Medical School, began experiments with the antifolate drug aminopterin.
In our case, the patient received maintenance pemetrexed, an antifolate drug, for 8 cycles.
In clinical practice, the antifolate pemetrexed, as the only FDA-approved therapeutic for MPM, is used in combination with platin compounds [6-10].
These enzymes undergo gene mutations causing the resistance of antimalarial antifolate [4 ].
Except antifolate antimalarial drugs other commonly used antimalarial agents are based on plant-derived compounds, quinine, and artemisinin derivatives, which remain vital drugs in the treatment of malaria [10,11].
Bilos et al., "MRP1 mediates folate transport and antifolate sensitivity in Plasmodium falciparum," FEBS Letters, vol.
Resistance to the antifolate drug pyrimethamine results from the accumulation of single nucleotide polymorphisms (SNPs) in the dihydrofolate reductase (dhfr) domain of the dihydrofolate reductase-thymidylate synthase (dhfr-ts) gene [15].
Currently, the combination of cisplatin with the antifolate agent pemetrexed is considered a gold-standard frontline chemotherapy for MPM [32], while VAAP as a single drug displayed remarkable activity against a panel of cancer cells, especially MPM-derived cells in the study by Yang et al.
Similar to antifolate pemetrexed which has been used to improve tumor uptake and kidney clearance of radiofolate, 2-PMPA as PSMA inhibitormay have great potential to be used in the PSMA-targeted treatment via coadministration [30].
Figure 2: Distribution of adverse drug reactions based on drug class Antibiotic 33% Antiepileptic 12% Antiviral 4% Anticoagulant 3% Antihypertensive 2% Antihypertensive 1% Antifolate 1% Beta agonist 1% Anticholinergic 1% Fibrinoltic 1% Antiemetic 1% colloid 1% NSAID 14% Antipsychotic 9% Steroid 2% Antiplatelet 2% Opioid 2% Anticancer 2% Antimaniac 1% Diuretic 1% Antiulcer 1% Antianginal 1% Antithyroid 1% Others 2% Note: Table made from pie chart.