antigenic determinant

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Related to antigenic determinant: hapten, Clonal selection

antigenic determinant

(Biochemistry) the specific part of an antigen molecule to which an antibody becomes attached
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˈɛp ɪˌtoʊp)

a site on an antigen at which an antibody can bind, the molecular arrangement of the site determining the specific combining antibody. Also called antigenic determinant .
[1970–75; epi- + -tope < Greek tópos place; compare topo-]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.antigenic determinant - the site on the surface of an antigen molecule to which an antibody attaches itself
immunology - the branch of medical science that studies the body's immune system
site, situation - physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides"
antigen - any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
The identification and characterization of residues important for binding within structurally defined antigenic determinant are the aim of functional epitope mapping tools.
Analysis of the antigenic determinant groups of the mannan of Candida albicans serotype A.
The HBsAg main antigenic determinant (a determinant) is encoded by amino acid residues from 124 to 147 within the major hydrophilic loop of HBsAg (amino acids 101 to 164) [12].
Mapping of antigenic determinant regions of the Bor56 protein of Orientia tsutsugamushi.
One such method comprises a) contacting said bodily fluid with said MuSK or an antigenic determinant thereof; and b) detecting any antibody-antigen complexes formed between said receptor tyrosine kinase or an antigenic fragment thereof and antibodies present in said bodily fluid, wherein the presence of said complexes is indicative of said mammal suffering from said neurotransmission or developmental disorders.
Monoclonal antibody immunoradiometric assay for an antigenic determinant (CA 72) on a novel pancarcinoma antigen.
A better understanding of the structure of the allergen and its gene would allow design of non-allergenic fragments carrying the antigenic determinant similar to the hypoallergen.
VP1 residue 145 has previously been identified as a key antigenic determinant, of which substitution can significantly affect the neutralizing activity (23,38).
The antigenic determinant in the cSOD2 were predicted according to the methods of Kolaskar and Tongaonkar method (1990) and the antigenicity score of more than 1.0 for at least six amino acid residues was considered.
coli strain F18 (F18ab and F18ac), which possess the variant-specific antigenic determinant "b" and "c", respectively, in addition to a common antigenic determinant "a".
The antigenic determinant sites located on the N protein were determined according to the specific binding of a mAb to the particular yeast-displayed protein.