A first Phase I/IIa clinical trial with iadademstat in refractory and relapsed acute leukemia patients demonstrated the safety and good tolerability of the drug and preliminary signs of antileukemic
activity, including a CRi.
imbricatus is important because it shows various biological activities, such as antileukemic
, anticancer, apoptotic-inducing, and anti-inflammatory.
Phenethyl isothiocyanate exhibits antileukemic
activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways.
Following a clinical and regulatory strategy defining Type C dialogue with the FDA, the company plans to proceed with a clinical study design and biostatistical plan to support a Phase 3 registrational study for maintenance therapy for AML patients who have achieved complete remission after second line antileukemic
therapy, or CR2.
Acute myeloid leukemia (AML) is a hematopoietic neoplasm of the myeloid line of blood cells. Clinically, secondary heart tumors usually remain silent. Several mechanisms have been suggested for the occurrence of cardiovascular disease during acute leukemia: leukemic thrombi or leukostasis in major arteries, leukemic infiltration into the myocardium or pericardium, and disorders of coagulation secondary to leukemia and antileukemic
therapies. We present a case of intracavitary heart masses in three heart chambers by AML.
activity of carnosic acid-rich rosemary extract and the 19-nor Gemini vitamin D analogue in a mouse model of systemic acute myeloid leukemia.
Derivatives of anthracene-9, 10-dione have attracted the attention of medicinal chemists due to a wide spectrum of significant pharmacological activities such as anti-tumour (Ashnagar et al., 2010; Ge and Russell, 1997), anti-inflammatory (Yadav et al., 2010), antimalarial (Osman et al., 2010; Yadav et al., 2010), antioxidants, antimicrobial (Yadav et al., 2010; Xiang et al., 2008), antifungal (Rath et al., 1995), antileukemic
(Chang and Lee, 1984), antiviral and anti-HIV properties (Alves et al., 2004; Schinazi et al., 1990).
mechanisms induced by BET inhibitors, such as JQ1, are currently not well understood but are believed to involve suppression of MYC.
activity of glycyrrhetinic acid," Nature, vol.
Our findings indicate a high percentage of central adiposity among subjects treated for childhood cancer, especially after antileukemic
therapy, although the percentage of obese/overweight survivors was not high.
Castillo-Caro et al., "Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory T cells without diminishing antiviral and antileukemic
activity," Clinical Cancer Research, vol.
Luetkens et al., "5-azacytidine promotes an inhibitory T-cell phenotype and impairs immune mediated antileukemic
activity," Mediators of Inflammation, vol.