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Related to antimetabolite: methotrexate


 (ăn′tē-mĭ-tăb′ə-līt′, ăn′tī-)
A substance that closely resembles an essential metabolite and therefore inhibits physiological reactions involving that metabolite.

an′ti·met′a·bol′ic (-mĕt′ə-bŏl′ĭk) adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Pharmacology) any drug that acts by disrupting the normal growth of a cell. Sulfonamide drugs are antimetabolites and some antimetabolites are used in cancer treatment
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˌæn ti məˈtæb əˌlaɪt, ˌæn taɪ-)

any substance that interferes with growth by competing with a nutrient metabolite for receptors or enzymes in the body, used esp. for treating certain cancers.
an`ti•met`a•bol′ic (-ˌmɛt əˈbɒl ɪk) adj.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite
antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function
fluorouracil - an antimetabolite used to treat certain cancers
mercaptopurine, Purinethol - a drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia
amethopterin, methotrexate, methotrexate sodium - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
According to the company, BST-236 is a novel antimetabolite, a pro-drug of the chemotherapeutic drug cytarabine.
Results of a multicenter, double-blind Phase II trial conducted by the Princess Margaret, California, Chicago and Mayo Phase II Consortia will show for the first time increased OS data with the Wee-1 inhibitor adavosertib when associated with the antimetabolite therapy Gemcitabine."
Methotrexate (MTX) is a folic acid analogue and an antimetabolite agent, which is commonly used in blood and solid organ malignancies, dermatological and rheumatic diseases and ectopic pregnancy termination (Smith et al., 2008).
The most commonly utilized topical therapy for VAIN is the antimetabolite chemotherapeutic agent 5-fluorouracil (5FU).
Pain related to treatment, side effects and cost can be determining factors in choosing a therapy.9 5-Fluorouracil (FU) is an antimetabolite that suppresses cell division and causes cell cycle arrest.10 Topical 5-FU is used in the treatment of warts but is not very effective.11 Intralesional injection of 5-FU permits higher drug concentrations throughout the lesion and previous study has shown it effectiveness in treatment of warts.12
The study further evaluated the synergistic effects of extracts from the two plants with 5-Fluorouracil, an antimetabolite and anti-cancer chemotherapeutic drug that is widely used in the treatment of colon, prostate, breast cancer.A number of side effects have been observed in the usage of the drug alone including hair loss, nausea and vomiting, loss of appetite and diarrhea but when it was given with a combination of the two extracts, no side effects were observed.
I'd prefer not to be injecting an antimetabolite into somebody if I can help it," Dr.
He was then started on pemetrexed, a folate antimetabolite chemotherapy drug, for metastatic UC with plans to complete 6 cycles.
A few risk factors that may have predisposed our patient to the development of NE were her supratherapeutic tacrolimus level at admission, treatment with an antimetabolite (mycophenolate), treatment with other myelosuppressive medications such as prophylactic antibiotics, and elevated Epstein-Barr viral load.
Bleomycin is an antimetabolite agent acting on DNA synthesis inhibition.