In addition, hydrogen fluoride pyridine is also used in the formulation of analogs antimitotic
Indeed, independent of its antimitotic
activity, vinca alkaloid including VCR induce mitochondrial transmembrane potential loss and interfere and inhibit electron transport chain (ETC), leading to generate high levels of ROS and activate apoptosis (Muthuraman & Singh; Canta et al.; Vashistha et al.).
effect of ammonia decreased fungal growth because of the alkaline environment, so urea treated silages had higher aerobic stability .
PAC, derived from the bark of Taxus brevifolia and having an antimitotic
effect, has been used as a drug in some cancer therapy such as cancer of the uterus and breast cancer (9).
It is the only antimitotic
immunosuppressant agent with no major toxic effects on the marrow megakaryopoiesis (4).
Valayudha, Anti-inflammatory and Antimitotic
Activities of Lupeol Isolated from Leaves of Ixora Coccinea.
Till now, trabeculectomy is still the most efficient option for those with progressive glaucoma. Cicatrix is the major cause of postoperative bleb failure and significantly affects the long-term success rate of trabeculectomy.,,, The use of antimitotic
agents such as 5-fluorouracil and mitomycin C (MMC) has been widely accepted as the golden standard of trabeculectomy, apparently reducing the incidence of scar formation and enhancing bleb surviving rate.
Sliwmska et al., "Antimitotic
effect, G2/M accumulation, chromosomal and ultrastructure changes in meristematic cells of Allium cepa L.
It showed strong cytotoxicity against multiple tumor cell lines  and antimitotic
activity for the first cleavage  and inhibited the growth of several human leukemia cells .
Methotrexate being antimitotic
has been used to aid regression of the placenta although more and more authors do not agree with its use.
Ricardo et al., "The PLGA implant as an antimitotic
delivery system after experimental trabeculectomy," Investigative Opthalmology and Visual Science, vol.