Isoproterenol (Injection 1mg/ml), Labetalol (Injection 5mg/ml), Meglumine Antimoniate
(Injection 30%), Mercaptopurine (Tablets 50mg), Miltefosine Solid (Oral Dosage Form 10mg and 50mg), Phenoxymethylpenicillin (Powder for Oral Liquid 250mg/5ml), Procaine Penicillin (Injection 1MIU and 3MIU).
However, the first-line treatment of CL is meglumine antimoniate
, which is not produced locally.
Intralesional meglumine antimoniate
(MA) is one of these treatments; nonetheless, high cost, low compliance, and systemic toxicity have restricted the use of all these treatments.
KEYWORDS: Cutaneous leishmaniasis, Meglumine antimoniate
Factors associated to adherence to different treatment schemes with meglumine antimoniate
in a clinical trial for cutaneous leishmaniasis.
In Brazil, the available drugs are pentavalent antimoniate
and amphotericin B (deoxycholate and liposomal).
Keywords: Cutaneous leishmaniasis, intralesional injection, meglumine antimoniate
, trichloroacetic acid, topical therapy.
There are several treatment options available1,6 but meglumine antimoniate
(Glucantime)6 is still the treatment of choice.
A published study demonstrates an historical series of patients with visceral leishmaniasis that were treated with meglumine antimoniate
in a hospital for tropical diseases of Maceio-AL (Silveira et al., 2015).
Objective: To compare the efficacy of combined intra-lesional meglumine antimoniate
and cryotherapy versus cryotherapy alone for the treatment of cutaneous leishmaniasis in our population.
In vitro bir calismada MTT testi uygulanarak kalsiyum kanal blokoru olan verapamil ve meglumine antimoniate
kombinasyonunun meglumine antimonate'a gore promastigot ve amastigotlar uzerine daha etkili oldugu gosterilmistir (39).
The remaining dogs underwent treatment with a daily subcutaneous injection of meglumine antimoniate
(80-100 mg/kg) for a month and allopurinol administered orally (10 mg/kg/12 hours) and were followed up for six months.