antioestrogen


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antioestrogen

(ˌæntɪˈiːstrədʒən; ˌæntɪˈɛstrədʒən)
n
a drug that inhibits the activity of oestrogens
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
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[2] Antioestrogen clomiphene ensures regular and rhythmic synthesis and release of hCG.
The authors postulated that serum TGF-[beta]1 levels in women maybe under the control of antioestrogen hormones, ultimately resulting in the secretion of TGF-[beta]1 by-fetal human fibroblasts.
Antioestrogen adjuvant therapy for hormone sensitive BC reduces risk of recurrence and increases survival by 39% and 31% respectively.
reported that the combination therapy with antioestrogen and anti-RET in luminal breast cancer exerted a greater effect on cell growth than either therapy alone [22].
Bowler, "ICI 182,780, a new antioestrogen with clinical potential," Journal of Steroid Biochemistry and Molecular Biology, vol.
A novel dual-target steroid sulfatase inhibitor and antioestrogen: SR 16157, a promising agent for the therapy of breast cancer.
Antioestrogen action in experimental breast cancer.
Tamoxifen is not a pure antioestrogen, since it has an oestrogenic effect in skeletal muscles, in lipid metabolism and in various gynaecological tissues.
Inhibition of erbB receptor (HER) tyrosine kinases as a strategy to abrogate antioestrogen resistance in human breast cancer.
If complete surgical resection is not possible, treatment options include neoadjuvant radiotherapy to reduce tumour size to permit resection or achieve a possible cure;[21 postoperative brachytherapy or intraoperative radiation therapy to kill remaining tumour cells; non-steroidal inflammatory drugs, antioestrogen therapy (tamoxifen) or a combination thereof; and chemotherapy or targeted drug therapy.
The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4hydroxy-tamoxifen in human liver.
The influence of CYP2136, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z4-hydroxy-tamoxifen in human liver.