adjuvant therapy for hormone sensitive BC reduces risk of recurrence and increases survival by 39% and 31% respectively.
reported that the combination therapy with antioestrogen
and anti-RET in luminal breast cancer exerted a greater effect on cell growth than either therapy alone .
Bowler, "ICI 182,780, a new antioestrogen
with clinical potential," Journal of Steroid Biochemistry and Molecular Biology, vol.
action in experimental breast cancer.
Tamoxifen is not a pure antioestrogen
, since it has an oestrogenic effect in skeletal muscles, in lipid metabolism and in various gynaecological tissues.
Inhibition of erbB receptor (HER) tyrosine kinases as a strategy to abrogate antioestrogen
resistance in human breast cancer.
If complete surgical resection is not possible, treatment options include neoadjuvant radiotherapy to reduce tumour size to permit resection or achieve a possible cure;[21 postoperative brachytherapy or intraoperative radiation therapy to kill remaining tumour cells; non-steroidal inflammatory drugs, antioestrogen
therapy (tamoxifen) or a combination thereof; and chemotherapy or targeted drug therapy.
The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen
Z-4hydroxy-tamoxifen in human liver.
The influence of CYP2136, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen
Z4-hydroxy-tamoxifen in human liver.
Effects of a non-steroidal pure antioestrogen
, ZM 189,154, on oestrogen target organs of the rat including bones.