antioestrogen


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antioestrogen

(ˌæntɪˈiːstrədʒən; ˌæntɪˈɛstrədʒən)
n
a drug that inhibits the activity of oestrogens
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References in periodicals archive ?
Antioestrogen adjuvant therapy for hormone sensitive BC reduces risk of recurrence and increases survival by 39% and 31% respectively.
reported that the combination therapy with antioestrogen and anti-RET in luminal breast cancer exerted a greater effect on cell growth than either therapy alone [22].
Bowler, "ICI 182,780, a new antioestrogen with clinical potential," Journal of Steroid Biochemistry and Molecular Biology, vol.
Antioestrogen action in experimental breast cancer.
Tamoxifen is not a pure antioestrogen, since it has an oestrogenic effect in skeletal muscles, in lipid metabolism and in various gynaecological tissues.
Inhibition of erbB receptor (HER) tyrosine kinases as a strategy to abrogate antioestrogen resistance in human breast cancer.
If complete surgical resection is not possible, treatment options include neoadjuvant radiotherapy to reduce tumour size to permit resection or achieve a possible cure;[21 postoperative brachytherapy or intraoperative radiation therapy to kill remaining tumour cells; non-steroidal inflammatory drugs, antioestrogen therapy (tamoxifen) or a combination thereof; and chemotherapy or targeted drug therapy.
The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4hydroxy-tamoxifen in human liver.
The influence of CYP2136, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z4-hydroxy-tamoxifen in human liver.
Effects of a non-steroidal pure antioestrogen, ZM 189,154, on oestrogen target organs of the rat including bones.