antioncogene


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an·ti·on·co·gene

 (ăn′tē-ŏn′kə-jēn, -ŏng′-, ăn′tī-)
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Immunohistochemical expression of transforming growth factor beta 1 and nm-23 H1 antioncogene in prostate cancer: divergent correlation with clinicopathological parameters.
Promotion of cancer cell proliferation mediated by the binding of AFP receptors (AFPR), the activation of PI3K/AKT signal pathway, the stimulation of oncogene protein, and the dysfunction of PTEN antioncogene protein [26-32].
In nasopharyngeal carcinoma and gastric cancer, however, it was identified as an antioncogene and was shown to target FSCN1 and RegIV [43, 46].
Mice lacking intestinal S1P lyase exhibited greater disease activity of colitis-associated cancer (CAC); these include colon shortening, increase of cytokine levels, S1P accumulation, tumor formation, STAT3 activation, STAT3-activated microRNAs (miRNAs), and suppression of miR-targeted antioncogene products [107,108].