antisense


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Related to antisense: Antisense strand, Antisense drugs

an·ti·sense

 (ăn′tē-sĕns′, ăn′tī-)
adj.
Of or relating to a nucleotide sequence that is complementary to a sequence of messenger RNA. When antisense DNA or RNA is added to a cell, it binds to a specific messenger RNA molecule and inactivates it.

an•ti•sense

(ˌæn tiˈsɛns, ˌæn taɪ-)
adj.
of or pertaining to a gene that is derived from RNA or complementary DNA, is inserted in reverse orientation into a strand of DNA, and is used in genetic engineering to regulate genetic expression of a trait.
[1985–90]
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References in periodicals archive ?
OGX-011 is a second-generation antisense drug designed to specifically inhibit the production of clusterin, a cell-survival protein that is up-regulated in response to standard anti-cancer treatments.
The resulting antisense compounds shut down the cellular factory churning out a disease-causing protein.
Antisense Therapeutics Limited, Melbourne, Australia will conduct a "proof of concept" study of ATL1101 in patients with psoriasis.
Antisense molecules are tiny pieces of DNA or RNA designed to bind to a cell's own DNA or RNA and interfere with its activity.
covering broad applications in the field of nucleic acid technology and the second in Canada for antisense RNA (genetic antisense).
One approach involves small pieces of synthetic DNA, called antisense (SN: 6/10/89, p.
Using a technique called antisense genetics, Calgene researchers permanently endowed their tomato with a backward (antisense) copy of the gene for polygalacturonase (PG), a fruit-softening enzyme.
Using a new genetic technology called antisense, researchers have completely shut down the operation of a gene that can cause the walls of arteries to thicken, reducing blood flow to a trickle.