OGX-011 is a second-generation antisense
drug designed to specifically inhibit the production of clusterin, a cell-survival protein that is up-regulated in response to standard anti-cancer treatments.
The resulting antisense
compounds shut down the cellular factory churning out a disease-causing protein.
Therapeutics Limited, Melbourne, Australia will conduct a "proof of concept" study of ATL1101 in patients with psoriasis.
molecules are tiny pieces of DNA or RNA designed to bind to a cell's own DNA or RNA and interfere with its activity.
covering broad applications in the field of nucleic acid technology and the second in Canada for antisense
RNA (genetic antisense
One approach involves small pieces of synthetic DNA, called antisense
(SN: 6/10/89, p.
Using a technique called antisense
genetics, Calgene researchers permanently endowed their tomato with a backward (antisense
) copy of the gene for polygalacturonase (PG), a fruit-softening enzyme.
Using a new genetic technology called antisense
, researchers have completely shut down the operation of a gene that can cause the walls of arteries to thicken, reducing blood flow to a trickle.