antisense RNA


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antisense RNA

(ˈæntɪsɛns)
n
(Genetics) molecules transcribed, not from DNA in the usual way, but from DNA strands complementary to those that produce normal messenger RNA. Antisense RNA occurs in nature and is inhibitory on gene action. It can be produced synthetically and offers such therapeutic possibilities as turning off viral genes
Translations
ARN antisens
References in periodicals archive ?
It includes not only the insertion of a gene into the cell for expression, but also gene silencing with RNA interference (RNAi) and antisense RNA, aptamers (DNA or RNA polymers which bind to a protein target), and oncolytic viruses.
My lab has made pioneering contributions to the understanding of C9orf72 FTD/ALS, and reported the first structure of the repeat RNA, and the first description of both sense and antisense RNA aggregates in patient brain.
Some specific topics examined include clinical application of RNAs for cancer therapy, selection of target sites in RNA for antisense agents, and natural antisense RNA in mammals.
Antisense RNA technology used synthetic strands of RNA to deactivate messenger RNA, effectively blocking a gene's activity and preventing production of a particular protein.
The corresponding digoxigenin-labeled antisense RNA probes were prepared from pGEM-1 containing a BamH1-EcoR1 956-bp insert consisting of exon 3 and flanking intron sequences from the rat IGF-1 gene, and the pTRI-IGFR-human transcription template containing a 236-bp cDNA fragment of the human IGF-1R gene spanning exons 8-7 (Ambion, Austin, TX, USA).
One method, antisense RNA technology, proved to be unreliable.
Frechet foresees wide application for the technique in delivering antisense RNA, proteins or genes into cell interiors, and integrating with current methodologies.
When mRNA forms a duplex with a complementary antisense RNA sequence, one of the consequences is the blocking of translation.
Prior to this advance, researchers used the less robust antisense RNA technology to achieve the same goals.
They've also identified antisense RNA that helps control plasmid replication in lactococci.
Anti-HIV-1 antisense RNA was detected in all patients after 6 months and has been detected in 2 of the 5 subjects for periods up to 12 months.
covering broad applications in the field of nucleic acid technology and the second in Canada for antisense RNA (genetic antisense).