lot 1: intraosseous infusion needle with motor insertion, - lot 2: manual intra-osseous infusion needle, - lot 3: device for cadd portable pump, - lot 4: short venous catheter with valve, - lot 5: short venous catheter without fins, - lot 6: long-term peripheral venous catheter, - lot 7: adult central catheter, - lot 8: pediatric central catheter, - lot 9: central neonatalogical catheter, - lot 10: venous catheter epicutaneo cave, lot 11: arterial catheter - lot 12: peripherally inserted central catheter (picc) - lot 13: picc catheter dressing, - lot 14: venous implantable chamber, - lot 15: device for apomorphine
pump, - lot 16: plate of exsanguino transfusion, - lot 17: umbilical catheter set, - lot 18: male-female pe / pvc extension, - lot 19: male-male luer lock connector.
M2 PHARMA-February 2, 2018-Sunovion Apomorphine
Sublingual Film Meets Primary and Secondary Endpoints in Parkinson's Disease Patients
Objective: To investigate the effects of repeated doses of apomorphine
in rats exposed to unpredictable chronic mild stress.
Carefully weighed and gently restrained by a veterinary nurse, who valiantly managed to avoid his kisses, Tam was given a subcutaneous injection of apomorphine
, a drug that you might think was for pain relief but is actually a very powerful emetic.
Sunovion intends to advance the clinical development program for a novel formulation of apomorphine
(APL-130277), which is a product candidate designed to be a fast-acting, easy-to-use, sublingual thin film for the on-demand management of OFF episodes associated with Parkinson's disease (PD).
Drug or vehicle (5 [micro]M apomorphine
, 25 [micro]M haloperidol, or 0.
Different effects of levodopa and apomorphine
on blink reflex recovery cycle in essential blepharospasm.
Patients on drugs like heparin, testosterone, hydralazine, phenothiazines, papaverine, sildenafil, tadalafil, apomorphine
, and prostaglandin, which can induce penile erection were also excluded from the study.
For example, subcutaneous injections of apomorphine
have translated to positive effects on intestinal motility (improvement of the defecatory mechanisms and anorectal dysfunction [6, 32, 131, 132]) and UPDRS motor scores (in about 70% of PD patients ), although adverse effects such as orthostatic hypotension (in 50% of patients), nausea, and drowsiness (in 75% of patients) may occur following administration of this DA agonist [8, 134].
In its disruptive function, Serres's noise perhaps most resembles Burroughs's mythologized apomorphine
In order to evaluate the methanolic extract of Chrysanthellum indicum impact on brain activity, Yaro's group (10) used six tasks on albino mice or Wistar rats: the spontaneous motor activity test in mice (9), the stereotyped behaviour induction test in mice using amphetamine and apomorphine
(33, 34), the pentobarbitone sleeping time in mice test (35, 36), the haloperidol-induced catalepsy in rats test (8), the exploratory behaviour test in mice (37, 38) and the rota-rod test for motor coordination on different methanolic extract doses (12.
Research conducted at Cardiff University using psychoactive drugs on mice and rats such as amphetamine and apomorphine
involve studies investigating areas such as neurodegenerative diseases and drug addiction," a spokesman said.