The goal of this study was to determine the role of Fas-mediated apoptosis
in human epidermal aging.
has recently been identified as an important mechanism of cell death and evidence suggests that prevention of cell apoptosis
can improve survival in animal models of sepsis and endotoxaemia.
En esta revision se exponen los mecanismos por los cuales este metal puede inducir muerte celular, haciendo enfasis en apoptosis
, una forma fisiologica de control de la proliferacion celular, pero a traves de la cual se puede alterar el normal funcionamiento de diversos organos y sistemas.
They cover detecting apoptosis
and non-apoptotic cell death, characterizing modifications of apoptotic proteins during apoptosis
, analyzing the function of major regulators of apoptosis
and cell survival, and analyzing apoptosis
in different organs and in model organisms.
can also be induced by pathways that depend on the activation of the cellular immune response through Fas/Fas-L and TNFR, pathways that are involved in both tissue injuries and control mechanisms of the immune response.
Studies have shown that inhibition or depletion of RLIP76, a glutathione-conjugate transport protein that helps cells defend themselves against toxicants, causes apoptosis
in a number of cancer cell types.
Nuclear changes associated with apoptosis
were evaluated using DAPI nuclear stain and a TUNEL assay.
While many registered nurses are aware of necrosis, they may be unaware of the term apoptosis
(programmed cell death) (Gastman, Futrell, & Manders, 2003).
Montreal, Canada) obtained six patents on and around the Inhibitors of Apoptosis
(IAP) gene family.
Cyclacel Limited, the UK-based biopharmaceutical company, has demonstrated through state-of-the-art biomarker technology that CYC202 (R-roscovitine), its lead CDK inhibitor drug candidate, appears to induce cancer cell suicide or apoptosis
in patients receiving the drug.
or programmed cell death is a normal physiological phenomena, however, uncontrolled apoptosis
is a cause of neurodegeneration.
is induced through the mitochondrial pathway resulting in caspase-9 activation and downstream caspase-3 activation.