apoptosis


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ap·op·to·sis

 (ăp′əp-tō′sĭs, ăp′ə-tō′-)
n.
A natural process of self-destruction by degradative enzymes in certain cells, such as epithelial cells and erythrocytes, that are genetically programmed to have a limited lifespan or are damaged, as by irradiation or toxic drugs. Also called programmed cell death.

apoptosis

(ˌæpəpˈtəʊsɪs)
n
(Biology) biology the programmed death of some of an organism's cells as part of its natural growth and development. Also called: programmed cell death
[C20: from Greek: a falling away, from apo- + ptōsis a falling]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.apoptosis - a type of cell death in which the cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animal's survival
cell death, necrobiosis - (physiology) the normal degeneration and death of living cells (as in various epithelial cells)
Translations
References in periodicals archive ?
The goal of this study was to determine the role of Fas-mediated apoptosis in human epidermal aging.
Apoptosis has recently been identified as an important mechanism of cell death and evidence suggests that prevention of cell apoptosis can improve survival in animal models of sepsis and endotoxaemia.
En esta revision se exponen los mecanismos por los cuales este metal puede inducir muerte celular, haciendo enfasis en apoptosis, una forma fisiologica de control de la proliferacion celular, pero a traves de la cual se puede alterar el normal funcionamiento de diversos organos y sistemas.
They cover detecting apoptosis and non-apoptotic cell death, characterizing modifications of apoptotic proteins during apoptosis, analyzing the function of major regulators of apoptosis and cell survival, and analyzing apoptosis in different organs and in model organisms.
6) Apoptosis can also be induced by pathways that depend on the activation of the cellular immune response through Fas/Fas-L and TNFR, pathways that are involved in both tissue injuries and control mechanisms of the immune response.
Studies have shown that inhibition or depletion of RLIP76, a glutathione-conjugate transport protein that helps cells defend themselves against toxicants, causes apoptosis in a number of cancer cell types.
Nuclear changes associated with apoptosis were evaluated using DAPI nuclear stain and a TUNEL assay.
While many registered nurses are aware of necrosis, they may be unaware of the term apoptosis (programmed cell death) (Gastman, Futrell, & Manders, 2003).
Montreal, Canada) obtained six patents on and around the Inhibitors of Apoptosis (IAP) gene family.
Cyclacel Limited, the UK-based biopharmaceutical company, has demonstrated through state-of-the-art biomarker technology that CYC202 (R-roscovitine), its lead CDK inhibitor drug candidate, appears to induce cancer cell suicide or apoptosis in patients receiving the drug.
Apoptosis or programmed cell death is a normal physiological phenomena, however, uncontrolled apoptosis is a cause of neurodegeneration.
Apoptosis is induced through the mitochondrial pathway resulting in caspase-9 activation and downstream caspase-3 activation.