The conventional outflow pathway, consisting of the trabecular meshwork and a specialized vessel called Schlemm's canal, controls IOP and has been identified as the site of increased resistance to aqueous humor
outflow in POAG.
One thing researchers do know about glaucoma is that more than half of all cases are caused by too much fluid (aqueous humor
) in the eye, which increases intraocular pressure.
The submicron particles in LOTEMAX SM help improve drug exposure into the aqueous humor
is produced in the ciliary processes of the ciliary bodies by two mechanisms - by active secretion (80%) and through ultrafiltration of plasma (20%).
5-HT[sub]2A/2C receptors are also present in the ciliary body, and it is presumed that it indirectly increases ciliary body flow with an enhanced production of aqueous humor
. Direct activation of 5-HT[sub]7 receptions has been shown to increase aqueous production via a rise in cyclic adenosine monophosphate levels, and stimulation of 5-HT[sub]2A/2C receptors in the ciliary body indirectly enhances ciliary body blood flow, thus promoting the production of aqueous by the ciliary processes. Although the mechanism of the venlafaxine increasing IOP is still unclear, it is a beneficial warning for clinical treatment.
The exact mechanism of elevated IOP in POAG is not known, but an increased resistance in the outflow channels is believed for diminished outflow of aqueous humor
. Rohen6 examined 400 trabeculectomy specimens of glaucomatous eyes with ultra-structural analysis and found, three types of extracellular deposits containing glycoproteins within the cribriform layers of the trabecular meshwork.
Study conducted by Davies et al compared glucose levels in aqueous humor
of diabetic versus non diabetic individuals.
In a healthy eye, fluid called aqueous humor
flows into and out of the eye in equal amounts.
UH College of Optometry biomedical engineer Vijaykrishna Raghunathan has received $765,000 from the National Institutes of Health to examine an understudied part of glaucoma - the ebb and flow of aqueous humor
, the liquid in the eye whose regulation controls eye pressure.
Consultant ophthalmologist Dr Mukesh Joshi, of Nairobi's Laser Eye Centre, explains that there is a fluid in the front part of the eye known as the aqueous humor
. The fluid is continuously formed and drained at the corner of the eye also known as the angle of anterior chamber.