Treatment and Response to Induction Chemotherapy: All patients were given standard "3+7" induction chemotherapy with daunorubicin (45mg/m2)and cytarabine (100 mg/m2) followed by consolidation therapy with high dose cytosine arabinoside
(3g/m2 12hrly on day 1, 3 and 5).
Pre-transplant risk factors of SOS include liver dysfunction (hepatitis, fibrosis, cirrhosis, etc.), hepatic metastases, history of liver radiotherapy, hepatotoxic agents (including herbal remedies, gemtuzumab ozogamicin, melphalan, cytosine arabinoside
, and cyclophosphamide), infectious attacks, iron overload, history of stem cell transplantation, and advanced age.
with Daunorubicin or Adriamycin for Therapy of Acute Myelocytic Leukemia: A CALGB Study." Blood 60 (2): 454-62.
Gemtuzumab ozogamicin with or without interleukin 11 in patients 65 years of age or older with untreated acute myeloid leukemia and high-risk myelodysplastic syndrome: comparison with idarubicin plus continuous-infusion, high-dose cytosine arabinoside
. Blood 2002; 99: 4343-9.
Her ALL was treated with protocol CCG 1961, consisting of vincristine, cytosine arabinoside
, pegylated-asparaginase, doxorubicin, methotrexate, and cyclophosphamide.
All patients received hydrocortisone, cytosine arabinoside
and methotrexate intrathecally for CNS prophylaxis with no irradiation.
The incidence of cerebellar toxicity with high-dose arabinoside
cytarabine (HIDAC) is ~ 10%. It can be diagnosed in a way that the MRI brain reveals cerebellar atrophy and reversible white matter changes.
Yildiz, "Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside
," Pediatric Dermatology, vol.
As a salvage, in analogy to acute lymphoid leukemia, intrathecal combinational chemotherapy with methotrexate, cytosine arabinoside
, and dexamethasone (15 mg, 40 mg, and 4 mg, resp.) is often applied continuously until liquor clearance, usually in combination with high-dose chemotherapy, using drugs with known CNS penetration (methotrexate, cytosine arabinoside
, idarubicin, and thiotepa), together with high-dose dexamethasone, similar to what we normally do in CNS lymphoma.
performed [[sup.18]F]fluoroazomycin arabinoside
([[sup.18]F]FAZA) imaging on 67 EMT6 breast tumor-bearing mice and used the median tumor-to-background ratio to discriminate between hypoxic and normoxic tumors.
The patient underwent treatment with DDAVP for central diabetes and systemic chemotherapy consisting of (I) vinblastine (VBL; 8 mg/day, intravenous infusion) and prednisolone (PSL; 30 mg/day, intravenous infusion) on Day 1 and (II) cytosine arabinoside
(AraC; 200 mg/day, intravenous infusion) and PSL (30 mg/day, intravenous infusion) on Day 2 every 4 weeks.