It is characterized by ascending paralysis, areflexia
and raised protein in cerebrospinal fluid.
Bilateral vestibular areflexia
(Dandy's syndrome) was found at caloric stimulation.
The other well-described conditions included in this spectrum are rapidonset dystonia parkinsonism and CAPOS syndrome (cerebellar ataxia, areflexia
, pes cavus, optic atrophy and sensorineural hearing loss).
As an example of regional/clinical variant, MFS presents with its typical triad consisting of areflexia
, ataxia, and ophthalmoplegia whereas in acute sensory neuropathy, primarily sensory involvement is responsible for the clinical picture (12).
Patients were admitted with asymmetric, acute, and progressive weakness of limbs; areflexia
; and muscle pain.
The main pathologies that have been most searched and associated with DM are OAB syndrome, detrusor hyporeflexia, detrusor areflexia
, urge incontinence and stress UI.
Because it results from the same pathological process and also contributes to patients' instability and represents an integral part of the same syndrome, it was renamed to cerebellar ataxia neuropathy and vestibular areflexia
syndrome (CANVAS) .
The most frequently encountered clinical picture consists of relatively symmetrical muscular weakness that begins distally in the lower limbs, followed a few days later by the involvement of more proximal muscles such as those of the trunk, neck, and face, hypotonia, hyporeflexia, or areflexia
, paresthesia, and opthalmoplegia., GBS is highly diverse with respect to the presence, distribution, and extent of cranial nerve deficits, sensory symptoms, weakness, ataxia, pain, autonomic dysfunction, and the course of the disease.
Clinically, GBS is generally characterized by monophasic progression of bilateral weakness and hypo- or areflexia
Other findings included depigmented patches of itchy skin (Figure 1a, 1b), palmar desquamation, weakness, hypotonia, and areflexia
. The patient's history was otherwise insignificant.
The mutation of c.1634G>A was reported in GAN patient associated with distal limb weakness and generalized areflexia
Over time, this wasting may result in "areflexia
, overall muscle weakness, difficulty walking/standing/sitting, loss of strength of the respiratory muscles and respiratory distress, fasciculations of the tongue and difficulty swallowing".