aromatase


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a·ro·ma·tase

 (ə-rō′mə-tāz′, -tāz′)
n.
A key enzyme in the biosynthesis of steroids, especially in the conversion of androgens to estrogens.

[aromat(ic) (because the enzyme increases the number of aromatic carbon rings in the molecular structure of the compounds upon which it acts) + -ase.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

aromatase

(əˈrəʊməˌteɪz)
n
an enzyme that converts testosterone into an oestrogen
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
Risk was comparable in women on aromatase inhibitors (AIs) only and in those who used sequential tamoxifen followed by an AI, Reina Haque, Ph.D., reported at the San Antonio Breast Cancer Symposium.
It has been hypothesized that male and female sex differentiation is determined by aromatase activity in fish as Cyp19 gene is highly conserved in fish [12].
Therefore, hormone-receptor-positive breast cancer can be treated by either blocking the ER with agents such as the selective ER modulator tamoxifen, or by reducing the production of oestrogens with aromatase inhibitors (AIs) [2].
Aromatase is the name of the enzyme present in female and male bodies that transforms testosterone into estrogen in one step.
These mutations activate the estrogen receptor when there is no estrogen--as is the case when a patient takes an aromatase inhibitor," says lead study author Dan Robinson, PhD.
Aromatase is responsible for the final step in estrogen biosynthesis, catalyzing the aromatization of androstenedione and testosterone into estrone and estradiol, respectively (Haynes et al., 2003), and its activity determines the androgen-to-estrogen ratio in developing gonads (Navarro-Martin et al., 2009).
Conclusions: Everolimus combined with an aromatase inhibitor improved progression-free survival in patients with hormone-receptor-positive advanced breast cancer previously treated with nonsteroidal aromatase inhibitors.
Young that, for patients who have endometriosis and pelvic pain and who do not experience sufficient relief with an OC or GnRH agonist, a combination of an OC and an aromatase inhibitor, or NEA plus an aromatase inhibitor, may be effective.
Keywords: Aromatase inhibitors, CA Ovary, Granulosa cell tumour, Anastrozole, Oncology Royal Hospital.
Such reductions were subsequently confirmed in trials testing the other two potent aromatase inhibitors, letrozole and exemestane.
Sonia Servaja of Hospital del Mar in Barcelona, and colleagues, assessed the association between 25-hydroxy-vitamin D (25[OH]D) concentrations and bone loss at baseline, after 3 months of supplementation, and after 1 year, in patients receiving aromatase inhibitor therapy for early-stage breast cancer.
Not all breast cancer patients are eligible to take tamoxifen or aromatase inhibitors, but for some patients with estrogen-sensitive tumors, doctors are now prescribing both drugs, a five-year course of tamoxifen followed by a five-year course of an aromatase inhibitor.