Ibrance is now approved for adult patients with HR+, HER2- advanced or metastatic breast cancer in combination with an aromatase inhibitor
as initial endocrine based therapy in postmenopausal women or in men; or with fulvestrant in patients with disease progression following endocrine therapy.
To support the approval, Pfizer provided the results of an analysis of real-world data from electronic health records (EHRs) as additional supportive data to characterise the use of palbociclib in combination with endocrine therapy (aromatase inhibitor
or fulvestrant) in male patients with breast cancer based on observed tumour responses in this rare subset of patients with breast cancer.
Pharma-cogenetics and aromatase inhibitor
induced side effects in breast cancer patients.
, such as exemestane, anastrazole, and letrazole, are drugs which block this conversion in peripheral tissues.
induces complete sex in protogynous honeycomb grouper, Epinephelus merra.
work by blocking the production of the hormone oestrogen, stopping its ability to fuel some breast cancers.
Young women with stage I or II breast cancer who cannot take tamoxifen (due to contraindications or severe side effects) may receive a GnRH agonist alone, oophorectomy, or an aromatase inhibitor
+ GnRH agonist.
Estrogens are thought to help close epiphyseal growth plates; the idea of giving aromatase inhibitors
(AIs) is to block aromatase from converting androgens to estrogens in boys so that their growth plates stay open a bit longer and they grow taller.
Comparison of efficacy of aromatase inhibitor
and clomiphene citrate in polycystic syndrome.
Thirty-two percent of them used adjuvant tamoxifen only, 29% used an aromatase inhibitor
only, 20% switched from adjuvant tamoxifen to an AI, and the rest used neither endocrine therapy.
The present investigation was designed to better understand the aromatase based sex determination in fish using two functional treatments of tamoxifen (11p-hydroxyandrostenedione) an estrogen receptor blocker and letrozole (Cyp19) which is a known aromatase inhibitor