aromatase inhibitor


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aromatase inhibitor

n. Abbr. AI
Any of several drugs that affect the levels of steroids in the blood by inhibiting the enzyme aromatase. Aromatase inhibitors are used especially to lower estrogen levels to control the growth or prevent the recurrence of estrogen-sensitive tumors in post-menopausal women with breast cancer.

aromatase inhibitor

n
any of a class of drugs that inhibit the action of aromatase: used in the treatment of breast and ovarian cancer
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Ibrance is now approved for adult patients with HR+, HER2- advanced or metastatic breast cancer in combination with an aromatase inhibitor as initial endocrine based therapy in postmenopausal women or in men; or with fulvestrant in patients with disease progression following endocrine therapy.
To support the approval, Pfizer provided the results of an analysis of real-world data from electronic health records (EHRs) as additional supportive data to characterise the use of palbociclib in combination with endocrine therapy (aromatase inhibitor or fulvestrant) in male patients with breast cancer based on observed tumour responses in this rare subset of patients with breast cancer.
Pharma-cogenetics and aromatase inhibitor induced side effects in breast cancer patients.
Aromatase inhibitors, such as exemestane, anastrazole, and letrazole, are drugs which block this conversion in peripheral tissues.
Aromatase inhibitor induces complete sex in protogynous honeycomb grouper, Epinephelus merra.
Aromatase inhibitors work by blocking the production of the hormone oestrogen, stopping its ability to fuel some breast cancers.
Young women with stage I or II breast cancer who cannot take tamoxifen (due to contraindications or severe side effects) may receive a GnRH agonist alone, oophorectomy, or an aromatase inhibitor + GnRH agonist.
The opinion included a recommendation that allows oncologists the flexibility to prescribe Kisqali with any aromatase inhibitor (i.e., letrozole, anastrozole or exemestane) they deem most appropriate for their patient.
Estrogens are thought to help close epiphyseal growth plates; the idea of giving aromatase inhibitors (AIs) is to block aromatase from converting androgens to estrogens in boys so that their growth plates stay open a bit longer and they grow taller.
Comparison of efficacy of aromatase inhibitor and clomiphene citrate in polycystic syndrome.
Thirty-two percent of them used adjuvant tamoxifen only, 29% used an aromatase inhibitor only, 20% switched from adjuvant tamoxifen to an AI, and the rest used neither endocrine therapy.
The present investigation was designed to better understand the aromatase based sex determination in fish using two functional treatments of tamoxifen (11p-hydroxyandrostenedione) an estrogen receptor blocker and letrozole (Cyp19) which is a known aromatase inhibitor.