Anuscopic findings Anal cytology Normal LSIL ASCUS
N % N % N % Suggestive of low-grade 6 28.
In epithelial cell abnormality, ASCUS
, AGUS-NOS, and ASC-H make up 64.
The discordance scores were determined as follows: 0 if ASCUS
-H or above, 1 for LSIL, 2 for ASCUS
, and 3 for negative or unsatisfactory, which were considered screening failures.
Major Finding: Irrespective of HPV type, the vaccine reduced the risk for ASCUS
by 8%, the risk for LSILs by 14%, and the risk for HSILs by 41%.
Histology cor relation with atypical squamous cells of undetermined significance (ASCUS
) and low-grade squamous intraepithelial lesion (LSIL) cytology diagnoses: an argument to ensure ASCUS
follow-up that is as aggressive as that for LSIL.
was used as a cutoff, liquid-based cytology was less specific
We considered it an undercall when Pap showed normal, ASCUS
, LG SIL, or atypical squamous cells cannot exclude HG SIL (ASC-H) in the presence of histology of CIN 2 or worse.
results occur in 5%-10% of Pap tests, the researchers noted, adding that the "increased risk of SIL among HIV-infected women has been well documented, and several groups have reported the increased risk of progression [to] SIL in this population.
testing, the National Cancer Institute conducted the ALTS clinical trial that demonstrated sensitivity of 96% for detection of high-grade cervical disease and cancer and a sensitivity of just 85% for liquid-based cytology.
The trial, initiated in early 2006, screened more than 50,000 subjects and enrolled over 3,400 subjects, including more than 1,300 women with atypical or ASCUS
Pap test results.
= atypical squamous cells of uncertain significance; LSIL= low grade squamous intra-epithelial lesion; HSIL=high grade squamous intraepithelial lesion; SCC = squamous cell carcinoma.
Inflammatory smears were seen in 70 patients (35%); 40 patients (20%) reported as ASCUS
were subjected to High Risk Capture II assay (for HPV 16, 18, 45, 56, 58) and high-risk HPV DNA was found in 20 (50%) of the patients.