Evaluating the risk of individual women with ASCUS
and LSIL findings in Pap testing is important because some of the abnormalities resolve in the absence of treatment, whereas others may progress to a pre-cancerous condition or cervical cancer.
Figure 5 includes projections for patients with current negative Pap and current negative hrHPV DNA cotest results, for those with current negative Pap results and no available current hrHPV DNA test results, for those with any current Pap result and current negative hrHPV DNA test results, for those with current ASCUS
Pap results and negative reflex hrHPV DNA test results, and finally for those with current negative Pap and positive hrHPV DNA combined test results.
A complete analysis of the study data has not yet been finalized; however, early results confirm findings from the National Institutes of Health-sponsored ASCUS
/LSIL Triage Study that highlighted the relevance and importance of high-risk oncogenic human papillomavirus (HPV) DNA subtypes within ASCUS
9 Diagnostic detection rates of thin-layer versus conventional screening Thin-layer Conventional smears (n = 18,712) (n = 11,521) % Change ASCUS
1, 3, 4) The diagnostic criteria for ASCUS
are subjective and are not reproducible.
Using the new technology, they saw a one-third decrease in ASCUS
diagnoses; and then calculated the costs of what each ASCUS
diagnosis generated in terms of follow-up within the next year, including office visits, biopsies, and colposcopies.
Wright will continue to serve as Associate Professor of Pathology at Columbia University, NY and as a member of the board of directors of the American Society of Colposcopy and Cervical Pathology, a member of the American Cancer Society's Task Force for Cervical Cancer, and chair of the American Society of Colposcopy and Cervical Pathology's Consensus Management Guideline, ASCUS
is not a single diagnostic entity, but rather encompasses a spectrum of cellular changes and reflects a variety of pathologic processes that cannot be more specifically categorized.
4% of ASCUS
progressed to HSIL and 7% of LSIL progressed to HSIL.
Prior to the introduction of these guidelines there was no national consensus on follow-up for women with inconclusive or ASCUS
Pap tests," said Dina Mody, MD, FCAP, chair of the College's Cytopathology Committee.
The category of ASCUS
has been changed to atypical squamous cells (ASC) with a slightly amended definition: "Cytologic changes suggestive of a squamous intraepithelial lesion that are quantitatively or qualitatively insufficient for a definitive interpretation.
Digene Corporation (Nasdaq: DIGE) and Cytyc Corporation (Nasdaq: CYTC) today announced that the American Medical Women's Association (AMWA) has developed new patient guidelines that recommend testing for human papillomavirus (HPV) for the millions of women each year who receive abnormal results known as ASCUS
following their routine Pap test.