asparaginase


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as·par·a·gin·ase

 (ə-spăr′ə-jə-nās′, -nāz′)
n.
An enzyme isolated from bacteria that catalyzes the hydrolysis of asparagine and is used in the chemotherapeutic treatment of leukemia.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

asparaginase

(əˈspærədʒɪˌneɪz; əˈspærədʒɪˌneɪs)
n
(Pharmacology) an enzyme used in treating leukaemia
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.asparaginase - antineoplastic drug (trade name Elspar) sometimes used to treat lymphoblastic leukemiaasparaginase - antineoplastic drug (trade name Elspar) sometimes used to treat lymphoblastic leukemia
antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Effect of different yeast concentration on L- asparaginase production by all isolates is as shown on Figure 11.
He was given imatinib mesylate (a tyrosine-kinase inhibitor) 400 mg/day and induction ALL regimen (including glucocorticoid, vincristine, anthracycline and asparaginase).
Three previous fairs allowed to collect more than 400 thousand som ($6,879) and purchase such drugs as flucanir, asparaginase, glucose, sodium chloride," said the arrangers.
Washington, Jan 19 ( ANI ): Scientists in Singapore have found that asparaginase (ASNASE) - the enzyme that degrades the amino acid asparagine and serves as a common chemotherapeutic agent - arrests Group A Streptococcus (GAS) growth in human blood and blocks bacteria's proliferation, thus initiating a new potential treatment against deadly Streptococcal infections.
To address these concerns, Novozymes introduced the asparaginase Acrylaway[R] in 2007, a product that is today used industrially in more than 30 countries in a wide range of consumer products such as biscuits, snacks and French fries.
ERYTECH Pharma SA has received clearance of its Investigational New Drug (IND) Application from the United States Food and Drug Administration (FDA) to initiate a Phase I clinical trial of its product ERYASP, L- asparaginase loaded erythrocytes, in patients 40 years or older with newly diagnosed Acute Lymphoblastic Leukemia (ALL).
A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity.
Common medications implicated include asparaginase, antiepileptics, steroids and sulphur-based drugs (1).
Para o tratamento da neoplasia, optou-se pela realizacao de quimioterapia com o protocolo LCVA-Short modificado, incluindo: vincristina (0,7mg/[m.sup.2]), ciclofosfamida (250mg/[m.sup.2]), asparaginase (400UI/Kg), prednisona (1mg/Kg), doxorrubicina (30mg/[m.sup.2]).
Table 3: View into a comparison of incidence antibodies USPI language Product name (a) Examples: USPI text Elspar The detection of antibody formation is highly (asparaginase) dependent on the sensitivity and specificity of the assay, and the observed incidence of antibody positivity in an assay may be influenced by several factors including sample handling, concomitant medications and underlying disease.
Methotrexate is followed by treatment with a second chemotherapy drug called asparaginase. In the new approach, patients are given a dose of methotrexate that is about 50 times the starting dose in the Capizzi regimen, and the asparaginase is not used.