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An endogenous antigen that stimulates autoantibody production, as in an autoimmune reaction.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
The autoimmune mechanisms leading to EIMs have been suggested to be related to many factors, including genetic susceptibility, antigenic display of autoantigen, aberrant self-recognition, and immunopathogenetic autoantibodies against organ-specific cellular antigens shared by the colon and extra-colonic organs.
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes.
Kobayashi K, Kishi M, Atsumi T, Bertolaccini ML, Makino H, Sakairi N, et al: Circulating oxidized LDL forms complexes with beta2glycoprotein I: implication as an atherogenic autoantigen. J lipid Res.
It indicated that the 120,000 a-fodrin molecule may be an important autoantigen in the pathogenesis of SS.
The first is cathelicidin (LL37), derived from keratinocyte and may be considered as an autoantigen since it is an antimicrobial peptide.
Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3.
They also found that CD4 memory T-cell clones from lupus patients that were specific to R06O autoantigen were stimulated by Ro60-containing bacteria.
lactis delivering the autoantigen human proinsulin and tolerance-enhancing cytokine IL-10, is designed to reduce T1D pathology by re-establishing immunological tolerance to islet antigens via the production of regulatory T-cells.
The autoantibodies were reported to recognize bone tissue transglutaminase (TTG) as the autoantigen of interest; however, their titers subsided following the adoption of a gluten-free diet (13).
For example, the presence of polymyositis/scleroderma autoantigen 2 (PM/Scl2), a highly specific nuclear autoantigen, indicates that exosomes may be involved in triggering autoimmunity.