In the most likely mechanism by which infection induces autoimmunity
, foreign antigens very often may bear sufficient structural similarity to self-antigens.
"The data presented in the patent application provides additional insight into the mechanism by which our lead product, Endometrial Regenerative Cell (ERC-124), suppresses autoimmunity
in animal models of multiple sclerosis and Type 1 diabetes," said CSO Thomas Ichim.
"Arih2 is responsible for the most fundamental and important decision that the immune system has to make - whether the immune response should be initiated and progressed or whether it should be switched off to avoid the development of chronic inflammation or autoimmunity
," the paper quoted research leader Dr Marc Pellegrini as saying.
Their strategy was to induce mammary gland failure in mice by immunisation with an antibody specific to a milk protein that resulted in autoimmunity
Methods: A total of 106 HCV infected individuals (not on any antiviral therapy), were screened for laboratory evidence of autoimmunity
(ANA, SMA, AMA, Anti LKM, Anti GPC, Anti Thyroid microsomal and RA factor).
May 9-13, 2012 8th International Congress on Autoimmunity
2012 Granada, Spain http://www2.kenes.com/ autoimmunity/pages/home.aspx
More than 32 million people in the United States have autoantibodies, which are proteins made by the immune system that target the body's tissues and define a condition known as autoimmunity
, a study shows.
Likewise, allergy, food intolerance, cancer, and immunodeficiency (all broad diseases that are immune in nature) cross and share autoimmunity
. This suggests that immature immune systems are promoted and prevented from natural selection in the era of antibiotics, but they pay the cost of fostered health dysfunctions or diseases exposed to the current complex hostile environment.
The research, published in the European Journal of Immunology, studies the relationship between the sunlight-dependent vitamin D3 hormone, immune cells, and the risk and severity of autoimmunity
in an experimental model.
The acquisition is expected to enhance Emergenta[euro](tm)s product development strategy and monoclonal antibody therapeutic capabilities, while adding oncology and autoimmunity
products to its portfolio, Emergent said in a statement.Country: , USASector: BiotechnologyTarget: Trubion Pharmaceuticals IncBuyer: Emergent BioSolutions IncDeal size in USD: 135.5mType: Corporate acquisitionStatus: Closed
Significantly high prevalence of thyroid autoantibodies has been noted in patients with chronic widespread musculoskeletal complaints (6), and an association between FM and thyroid autoimmunity
has been suggested (7, 8).
Highlights, which includes original articles, case reports, news, and reviews, will be published through an unconditional grant from A.