Also found in: Medical, Wikipedia.


 (ôk′sə-trŏf′ĭk, -trō′fĭk)
Requiring one or more specific substances for growth and metabolism that the parental organism was able to synthesize on its own. Used with respect to organisms, such as strains of bacteria, algae, or fungi, that can no longer synthesize certain growth factors because of mutational changes.

[Greek auxein, to increase; see auxin + -trophic.]

aux·ot′ro·phy (ôk-sŏt′rə-fē) n.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Mentioned in ?
References in periodicals archive ?
Thus, at least some HCC tumors may be auxotrophic for arginine and require arginine supply from extracellular sources (110).
In these models, the auxotrophic strains of Salmonella Typhimurium, A1 strain (deficient in leucine and arginine synthesis) and the A1-R strain (deficient in leucine and arginine synthesis, with greater capacity to eliminate tumor cells), maintained their antitumor activity and did not cause toxic effects in the host due to its greater affinity for tumor tissue [49].
Interestingly, the reversal of argininosuccinate lyase activity makes these cells auxotrophic for arginine, which can have therapeutic applications for FH-deficient cancers (35).
Therefore, the auxotrophic mutants which are unable to multiply in the environment were designed.
Of the 12 isolates, 7 were double auxotrophic mutants with G6P and G3P (mean MIC 384 mg/L), 3 were auxotrophic only for G3P (mean MIC 597 mg/L), and 2 were capable of using both substrates and exhibited high-level resistance (MIC >1,024 mg/L).
Auxotrophic selectable markers involved in amino acid or nucleotide biosynthesis have also been used.
More congruent nichespecific phenotypes were observed in isoleucine/valine auxotrophic A.
anomalus as a platform to produce recombinant proteins such as the design of specific expression vectors and the generation of auxotrophic strains.
Stationary growth cultures of histidine auxotrophic Salmonella typhimurium (2 x [10.sup.9] cells/mL) TA97, TA98, TA100, TA102, and TA1535 strains were obtained at 37[degrees]C in lysogenic broth (LB, 10 g/L tryptone; 5 g/L yeast extract; 10 g/LNaCl) containing 8 [micro]g/mL ampicillin and 2 [micro]g/mL tetracycline (only for TA102).
(1977) The isolation and preliminary characterisation of auxotrophic and analogue resistant mutants of the moss, Physcomitrella patens.
The colonies which showed growth on complete medium (containing all the essential amino acids) but not on minimal medium were considered as auxotrophic (mutants).The mutants were then screened for hyper- production of alginate against the parent strain by using the pre-optimized conditions for wild culture.
Mutants of Psm using pTn5cat1 were obtained through conjugal transfer of pMC505 containing the transposable element from the auxotrophic strain E.